For any laboratory or pharmaceutical company engaged in peptide synthesis, the quality of the raw materials directly correlates with the success of their research and product development. Fmoc-3-chloro-L-phenylalanine is a specialized non-proteinogenic amino acid derivative that offers unique advantages in peptide construction. This guide is designed to help procurement specialists and research scientists understand what to look for when they intend to buy this vital reagent.

Key Specifications to Consider

When sourcing Fmoc-3-chloro-L-phenylalanine, several key specifications are crucial for ensuring optimal performance in your synthesis:

  • Purity: The most critical parameter. Aim for materials with a purity of ≥99%, ideally verified by chiral HPLC. This minimizes side reactions and ensures the integrity of your peptide sequence.
  • Optical Purity (Enantiomeric Excess): As it's an amino acid derivative, maintaining the correct stereochemistry (L-form) is essential for biological activity. Look for specifications related to optical rotation or enantiomeric excess.
  • Appearance: Typically described as a white to off-white powder, consistency in appearance can be an early indicator of quality.
  • Solubility: Understanding its solubility in common SPPS solvents (like DMF or NMP) is important for efficient coupling reactions.
  • CAS Number: Confirming the correct CAS number (198560-44-0) ensures you are obtaining the intended chemical.

Why Choose Fmoc-3-chloro-L-phenylalanine?

The '3-chloro' substitution on the phenyl ring of phenylalanine provides distinct chemical properties that can be leveraged in peptide design. It can influence:

  • Aromatic Interactions: Affecting how the peptide folds or binds to its target.
  • Hydrophobicity: Modifying the peptide's overall solubility and membrane permeability.
  • Metabolic Stability: Potentially increasing the peptide's half-life in vivo by hindering enzymatic degradation.

These attributes make it valuable for applications ranging from designing enzyme inhibitors to developing peptide-based diagnostics.

Finding a Reliable Supplier and Competitive Price

The market for specialized biochemicals can be competitive. When you decide to purchase Fmoc-3-chloro-L-phenylalanine, consider the following when evaluating potential suppliers:

  • Manufacturer Reputation: Look for established companies with a proven track record in producing high-quality amino acid derivatives. Sourcing from a direct manufacturer often yields better quality and pricing.
  • Supplier Location: Suppliers based in major chemical manufacturing hubs, such as China, can often offer competitive pricing due to economies of scale.
  • Customer Support: Responsive customer service and readily available technical documentation (like CoAs) are indicators of a reliable partner.
  • Pricing: While competitive pricing is important, it should not come at the expense of quality. Compare quotes, but always prioritize suppliers who meet your purity and consistency requirements.

As a dedicated manufacturer and supplier of advanced chemical intermediates, we are committed to providing researchers with high-purity Fmoc-3-chloro-L-phenylalanine. We understand the importance of reliable sourcing and competitive price for your critical peptide synthesis projects. We encourage you to reach out to us to discuss your specific needs and explore how we can support your research goals.