In the intricate world of peptide synthesis, the selection of high-quality building blocks is paramount. Among these, Fmoc-O-tert-Butyl-L-Threonine (CAS 71989-35-0) stands out as a critical component, particularly for researchers and manufacturers engaged in the development of peptide-based therapeutics. As a leading supplier, understanding its properties and applications is essential for optimizing synthesis processes and achieving superior results.

Fmoc-O-tert-Butyl-L-Threonine is a derivative of the naturally occurring amino acid L-threonine. Its structure incorporates the Fmoc (9-fluorenylmethoxycarbonyl) protecting group on the alpha-amino group and a tert-butyl ester on the side-chain hydroxyl group. This strategic protection is key to its utility in solid-phase peptide synthesis (SPPS). The Fmoc group allows for selective deprotection under mild basic conditions, enabling stepwise elongation of the peptide chain without damaging the growing peptide or sensitive functional groups. Simultaneously, the tert-butyl group serves as a robust protecting group for the threonine side chain, preventing unwanted reactions during the coupling steps and ensuring the integrity of the synthesized peptide.

The primary advantage of using Fmoc-O-tert-Butyl-L-Threonine lies in its ability to facilitate the synthesis of complex and biologically active peptides. Its high purity, often exceeding 99.5% as verified by Chiral HPLC, is crucial. Impurities can lead to truncated sequences, side products, and reduced yields, ultimately impacting the efficacy and safety of the final peptide product. For procurement managers and R&D scientists, sourcing this intermediate from a reliable manufacturer in China ensures not only competitive pricing but also a consistent supply chain, vital for both research and commercial production.

The applications of Fmoc-O-tert-Butyl-L-Threonine extend across several critical areas within the pharmaceutical and biotechnology industries. It is a cornerstone for synthesizing therapeutic peptides, which are increasingly being developed for a wide range of diseases, from metabolic disorders to cancer. Furthermore, it plays a role in protein engineering, where modified amino acids are incorporated to enhance protein stability, activity, or cellular uptake. Its utility also spans bioconjugation, enabling the precise attachment of peptides to other molecules for targeted drug delivery or diagnostic imaging.

For organizations looking to buy Fmoc-O-tert-Butyl-L-Threonine, partnering with a reputable supplier means gaining access to detailed product specifications, including optical activity and solubility data, which are essential for process validation. Inquiries regarding bulk purchase, lead times, and custom synthesis options are welcome. By choosing quality, you invest in the success of your peptide synthesis and drug development programs. We are committed to being your trusted partner for all your peptide synthesis reagent needs.