Peptide synthesis is a cornerstone of modern drug discovery and biopharmaceutical research. The ability to precisely engineer peptide sequences with specific functionalities is critical for developing new therapeutics. Among the vast array of building blocks available, N-Boc-4-fluoro-L-phenylalanine stands out as a particularly valuable component for chemists seeking to enhance peptide properties.

Why N-Boc-4-fluoro-L-phenylalanine?

N-Boc-4-fluoro-L-phenylalanine, identified by its CAS number 41153-30-4, is a derivative of the naturally occurring amino acid phenylalanine. Its structure incorporates two key features that make it highly desirable for advanced applications: the N-Boc (tert-butyloxycarbonyl) protecting group and a fluorine atom at the 4-position of the phenyl ring. The Boc group is a standard and effective protecting group in peptide synthesis, ensuring controlled coupling reactions and preventing unwanted side reactions. The presence of fluorine, a small and electronegative atom, can significantly alter the electronic properties and metabolic stability of a peptide. This fluorination can lead to improved binding affinity to target receptors, enhanced bioavailability, and increased resistance to enzymatic degradation, all crucial factors in the development of effective pharmaceutical agents.

Applications in Drug Discovery and Medicinal Chemistry

As a leading manufacturer and supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. recognizes the importance of high-quality reagents for critical research. N-Boc-4-fluoro-L-phenylalanine is extensively used in:

  • Peptide Synthesis: It serves as a direct building block in solid-phase or solution-phase peptide synthesis, allowing researchers to introduce a fluorinated phenyl side chain into peptide sequences. This modification can lead to novel peptide drugs with improved pharmacological profiles.
  • Drug Discovery: In the early stages of drug discovery, incorporating fluorinated amino acids like N-Boc-4-fluoro-L-phenylalanine can help chemists design novel candidate molecules with optimized pharmacokinetics and pharmacodynamics.
  • Medicinal Chemistry: This compound is instrumental for structure-activity relationship (SAR) studies, enabling researchers to probe the impact of fluorine substitution on peptide-target interactions.
  • Protein Engineering: Researchers utilize it to create modified proteins or enzymes for specific functions, studying how the altered amino acid sequence affects protein stability and catalytic activity.

Sourcing High-Purity N-Boc-4-fluoro-L-phenylalanine from a Reliable Supplier

For procurement managers and research scientists, sourcing high-purity chemical intermediates is paramount. NINGBO INNO PHARMCHEM CO.,LTD. offers N-Boc-4-fluoro-L-phenylalanine with a guaranteed purity of ≥99% (HPLC). We are a trusted manufacturer and supplier, committed to providing competitive pricing and reliable delivery for bulk purchases. By choosing us, you ensure that your peptide synthesis projects and drug discovery endeavors are supported by top-tier raw materials. We encourage you to request a quote for N-Boc-4-fluoro-L-phenylalanine and explore how our quality products can accelerate your innovation in the pharmaceutical and biotechnology sectors.