In the intricate field of peptide synthesis, the selection of high-quality building blocks is fundamental to achieving successful and reproducible results. Among these crucial components are Fmoc-protected amino acids, which facilitate the widely adopted Fmoc solid-phase peptide synthesis (SPPS) methodology. One such important derivative is Fmoc-3-L-Ala(2-thienyl)-OH, identified by its CAS number 130309-35-2. This article delves into the significance of this specific amino acid derivative and guides you on how to effectively procure it from reliable manufacturers.

Fmoc-3-L-Ala(2-thienyl)-OH is an L-alanine derivative where the beta-carbon is substituted with a 2-thienyl group, and the alpha-amino group is protected by the fluorenylmethyloxycarbonyl (Fmoc) group. The presence of the thienyl ring introduces unique electronic and steric properties, making this amino acid particularly useful for creating peptides with modified structures or specific biological activities. Its CAS number, 130309-35-2, serves as a unique identifier for this chemical entity, ensuring that researchers and procurement specialists can precisely specify and locate the desired compound from suppliers.

The primary application of Fmoc-3-L-Ala(2-thienyl)-OH lies in its role as a monomer in SPPS. The Fmoc protecting group is base-labile, allowing for its selective removal under mild conditions without disturbing other acid-labile protecting groups on side chains. This orthogonality is key to the success of Fmoc SPPS. The 2-thienyl side chain can impart enhanced stability, unique binding interactions, or altered pharmacokinetic profiles to the resulting peptide. Therefore, researchers in drug discovery, proteomics, and materials science often seek out this specialized amino acid to engineer peptides with tailored functionalities. When you need to buy this compound, look for suppliers that explicitly list the CAS 130309-35-2 and guarantee high purity.

For those looking to purchase Fmoc-3-L-Ala(2-thienyl)-OH, engaging directly with manufacturers or their authorized distributors is often the most efficient route. This ensures you receive authentic, high-quality material and can benefit from competitive pricing, especially when ordering in larger quantities. Understanding the specifications and purity levels offered by different suppliers is crucial. A reputable manufacturer will provide comprehensive documentation, including Certificates of Analysis, to confirm the product's integrity. This diligence is essential for critical applications where the success of your research or manufacturing process depends on the reliability of your raw materials. We pride ourselves on being a leading supplier of specialized amino acid derivatives like CAS 130309-35-2, offering excellent value and consistent quality to meet your peptide synthesis requirements.