In the realm of peptide synthesis, the precise selection and quality of building blocks are fundamental to achieving successful outcomes. Fmoc-N-Me-Thr(tBu)-OH, identified by its CAS number 117106-20-4, is a highly utilized derivative in Fmoc-based solid-phase peptide synthesis (SPPS). Its unique structural features and the reliable supply from reputable manufacturers are key to its widespread application. NINGBO INNO PHARMCHEM CO.,LTD., as a dedicated supplier and manufacturer from China, plays a significant role in ensuring researchers have access to this vital compound.

Understanding the Utility of Fmoc-N-Me-Thr(tBu)-OH

Fmoc-N-Me-Thr(tBu)-OH is a modified L-threonine derivative where the amino group is protected by the Fmoc moiety, the nitrogen carries a methyl group, and the hydroxyl group of the side chain is protected by a tert-butyl ether. This specific protection strategy is designed for controlled and selective coupling during SPPS. The N-methylation can alter the conformational preferences and metabolic stability of the resulting peptide, while the t-butyl ether offers orthogonal protection, being stable under the Fmoc deprotection conditions but cleavable during final resin cleavage.

Key Factors for Successful Procurement

When procurement professionals or research scientists look to buy Fmoc-N-Me-Thr(tBu)-OH, several critical factors influence their decision:

  • Purity and Consistency: The purity of Fmoc-N-Me-Thr(tBu)-OH directly impacts coupling efficiency and the purity of the synthesized peptide. Suppliers must provide reliable purity data (e.g., HPLC analysis showing >98% purity) and consistent batch-to-batch quality.
  • Accurate Chemical Information: Beyond the CAS number 117106-20-4, users need complete chemical formula (C24H29NO5) and molecular weight (411.49 g/mol) for stoichiometric calculations.
  • Supplier Reputation and Service: A supplier’s reputation for reliability, transparent communication, and responsive customer service is invaluable. Knowing you can obtain a quote quickly or get technical support when needed is a significant advantage.
  • Regulatory Compliance and Documentation: For pharmaceutical applications, ensuring the supplier adheres to relevant quality standards and provides necessary documentation (like CoAs and MSDS) is crucial.

NINGBO INNO PHARMCHEM CO.,LTD.: Your Strategic Partner in China

NINGBO INNO PHARMCHEM CO.,LTD. is a distinguished manufacturer and supplier of specialty chemicals and pharmaceutical intermediates, including Fmoc-N-Me-Thr(tBu)-OH (CAS 117106-20-4). We are committed to providing products of exceptional quality and consistency, understanding their importance in sophisticated synthesis. Our operations in China are geared towards ensuring reliable supply, competitive pricing, and excellent customer support, making us an ideal partner for your peptide synthesis needs. We invite you to inquire about purchasing this essential building block to enhance your research and development projects.

For inquiries or to purchase Fmoc-N-Me-Thr(tBu)-OH, please contact NINGBO INNO PHARMCHEM CO.,LTD., your trusted source for advanced chemical synthesis materials.