Peptide synthesis stands as a cornerstone in biochemical research and pharmaceutical development. The ability to precisely assemble amino acid sequences is crucial for creating novel therapeutics, diagnostic tools, and functional biomaterials. At the heart of efficient peptide synthesis lies the selection of effective coupling agents. Among these, N,N'-Carbonyldiimidazole (CDI), CAS 530-62-1, has emerged as a highly regarded reagent due to its versatility, mild reaction conditions, and the formation of relatively benign byproducts.

As a leading manufacturer and supplier of high-purity CDI, we understand the critical demands of researchers and production chemists. Our commitment is to provide a chemical that not only meets stringent quality standards but also facilitates seamless and efficient synthesis processes. This article delves into the role of CDI in peptide synthesis and highlights the advantages of sourcing this essential compound from a reliable chemical manufacturer.

The Mechanism of CDI in Peptide Bond Formation

The formation of a peptide bond involves the coupling of a carboxylic acid group of one amino acid with the amino group of another. This process typically requires activation of the carboxylic acid to make it more susceptible to nucleophilic attack by the amine. CDI excels in this role by reacting with a carboxylic acid to form a highly reactive acyl imidazole intermediate. This intermediate then readily reacts with an amine, forming the desired amide (peptide) bond. The key byproducts of this reaction are carbon dioxide and imidazole, which are generally easy to remove and pose minimal issues for downstream purification.

Why Choose Our CDI for Your Peptide Synthesis?

When you buy N,N'-Carbonyldiimidazole from us, you are investing in quality and reliability. Our product, with an assay of ≥98.0%, ensures predictable and reproducible results, minimizing the risk of side reactions and maximizing the yield of your target peptides. As a dedicated manufacturer in China, we maintain strict quality control throughout our production process, from raw material sourcing to final product packaging.

Benefits of Using High-Purity CDI:

  • Enhanced Reactivity: The acyl imidazole intermediate formed is highly electrophilic, leading to efficient coupling.
  • Mild Reaction Conditions: CDI-mediated reactions often proceed at room temperature, preserving the integrity of sensitive amino acid side chains and minimizing racemization.
  • Easy Workup: The volatile nature of CO2 and the water-soluble nature of imidazole simplify purification processes.
  • Broad Compatibility: CDI is compatible with both solution-phase and solid-phase peptide synthesis strategies.

A Trusted Supplier for Your Chemical Needs

For procurement managers and research scientists, securing a consistent supply of high-quality reagents is paramount. We offer N,N'-Carbonyldiimidazole in bulk quantities, catering to both research and large-scale production requirements. Our established position as a chemical supplier ensures that you receive not only a superior product but also exceptional customer service and technical support. If you are looking for a dependable peptide synthesis reagent manufacturer, consider partnering with us. We are committed to facilitating your scientific advancements through the provision of essential, high-performance chemical building blocks.

To inquire about N,N'-Carbonyldiimidazole price or to request a quote for bulk purchase, please contact our sales team. We look forward to supporting your next synthesis project.