For scientists engaged in peptide synthesis, particularly on a large scale or for complex sequences, optimizing yields and ensuring product purity are constant objectives. NINGBO INNO PHARMCHEM CO.,LTD. is proud to supply Boc-Asn(Trt)-OH, a specialized building block designed to address these very challenges. This N-alpha-Boc-N-gamma-trityl-L-asparagine, identified by CAS 132388-68-2, is instrumental in achieving superior outcomes in Solid-Phase Peptide Synthesis (SPPS).

The inherent reactivity of the asparagine side chain, specifically the amide group, can lead to undesirable side reactions during peptide chain elongation. The formation of succinimide or aspartimide rings is a common issue that complicates purification and reduces the overall yield of the target peptide. By employing Boc-Asn(Trt)-OH, researchers can effectively circumvent these problems. The bulky trityl group acts as a robust protecting group for the side chain, preventing intramolecular cyclization. This protection strategy is vital for maintaining the integrity of the asparagine residue throughout the synthesis process.

Furthermore, the improved solubility imparted by the trityl moiety in Boc-Asn(Trt)-OH is a significant advantage. Many protected amino acids can suffer from poor solubility, leading to incomplete coupling reactions and the need for harsher conditions. With Boc-Asn(Trt)-OH, the process is smoother, requiring less optimization and leading to more reproducible results. This is particularly beneficial when considering the purchase of this material for bulk peptide synthesis projects where consistency and efficiency are critical economic factors.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality intermediates that empower groundbreaking research. The availability of Boc-Asn(Trt)-OH at competitive prices allows more research groups to benefit from its advanced properties. Whether you are developing peptide-based therapeutics, diagnostic agents, or exploring fundamental biochemical pathways, incorporating this trityl-protected asparagine derivative into your SPPS strategy is a proven method for optimizing yields and ensuring the highest purity of your synthesized peptides.