The field of targeted protein degradation, particularly through Proteolysis Targeting Chimeras (PROTACs), has revolutionized drug discovery. Central to the efficacy of PROTAC molecules is the linker that connects the target protein binder to the E3 ligase binder. Among the critical components for building these linkers, 11-Aminoundecanoic Acid (CAS 2432-99-7) stands out as a versatile and highly sought-after building block.

As a chemical intermediate, 11-Aminoundecanoic Acid provides a flexible alkyl chain that is crucial for optimizing the spatial arrangement and physicochemical properties of PROTACs. Its structure, featuring both an amine and a carboxylic acid group separated by a ten-carbon chain, allows for facile conjugation and fine-tuning of linker length and flexibility. This adaptability is key to achieving efficient binding to both target proteins and E3 ligases, thereby promoting effective ubiquitination and subsequent degradation.

Researchers looking to buy 11-Aminoundecanoic Acid for their PROTAC synthesis endeavors require a reliable supplier that guarantees high purity and consistent quality. Manufacturers specializing in pharmaceutical intermediates, particularly those based in China, often offer competitive pricing and large-scale production capabilities. When sourcing this compound, paying attention to its purity (typically 97% min) is paramount to ensure successful and reproducible experimental outcomes.

Beyond its role in PROTACs, 11-Aminoundecanoic Acid is also recognized for its applications in creating N-carboxyalkylpeptides, which function as matrix metalloproteinase inhibitors. These inhibitors are valuable in various therapeutic areas. Furthermore, its use in synthesizing analogues targeting apoptosis in cancer cells, such as thapsigargin derivatives, underscores its importance in oncological research.

For scientists and procurement managers seeking to advance their drug discovery programs, understanding the sourcing landscape for key intermediates like 11-Aminoundecanoic Acid is essential. Partnering with reputable manufacturers and suppliers ensures a stable supply chain and access to high-quality materials, accelerating the development of novel therapeutics. When considering your next purchase, look for suppliers that emphasize quality control and can provide detailed specifications for their 11-Aminoundecanoic Acid, ensuring it meets the demanding requirements of pharmaceutical synthesis.