In the demanding world of chemical synthesis, especially within the pharmaceutical and fine chemical sectors, the selection of precise and reliable intermediates is critical to achieving successful outcomes. 5-Methoxyindole-3-acetonitrile, identified by CAS number 2436-17-1, stands out as a versatile and valuable compound for a wide array of synthetic applications. For R&D scientists and procurement managers looking to buy this intermediate, understanding its characteristics and sourcing strategies is key to optimizing their synthetic routes and ensuring product quality.

Understanding the Chemical Profile

5-Methoxyindole-3-acetonitrile is a white to off-white powder with a molecular formula of C11H10N2O and a molecular weight of 186.21 g/mol. Its melting point typically falls within the range of 65-69°C. This compound is recognized for its utility as a fundamental building block in organic chemistry. The presence of the indole ring system, functionalized with a methoxy group and an acetonitrile side chain, provides multiple points for chemical modification and elaboration. This structural versatility makes it an attractive starting material for creating more complex molecules with desired properties.

Strategic Applications in Synthesis

The primary applications of 5-Methoxyindole-3-acetonitrile (CAS 2436-17-1) are rooted in its role as a synthetic intermediate:

  • Pharmaceutical Intermediate: It is extensively used in the synthesis of various pharmacologically active compounds. For example, it serves as a precursor for indole-N-acetic acid derivatives, which have been explored for their potential as aldose reductase inhibitors to treat diabetic complications. Purchasing this intermediate from reputable manufacturers ensures the necessary purity for these sensitive syntheses.
  • Research Chemical: In academic and industrial research settings, 5-Methoxyindole-3-acetonitrile is employed as a valuable reagent for exploring new chemical reactions and developing novel compounds. Its well-defined properties make it suitable for both small-scale laboratory experiments and larger pilot studies.
  • Precursor for Bioactive Molecules: The indole scaffold is a common feature in many natural products and drugs. 5-Methoxyindole-3-acetonitrile provides an efficient way to introduce this structural motif, facilitating the synthesis of compounds with potential biological activity, including those related to melatoninergic pathways.

Sourcing and Procurement Considerations

When procuring 5-Methoxyindole-3-acetonitrile, prioritizing purity (typically 98%) and reliability of supply is essential. As a B2B purchaser, you should seek out established manufacturers and suppliers, particularly those based in China, known for their chemical production capabilities. Requesting detailed product specifications, including CoA and MSDS, is a standard practice. When contacting a manufacturer for a price quote, be prepared to specify your required quantity, whether it's for grams for research or kilograms for pilot production, to ensure you receive accurate pricing and delivery information.

Conclusion

5-Methoxyindole-3-acetonitrile (CAS 2436-17-1) is a critical intermediate that can significantly enhance the efficiency and success of organic synthesis projects. By understanding its chemical properties and application scope, and by partnering with trusted chemical manufacturers, researchers and formulators can leverage this compound to accelerate their product development and innovation efforts. For cost-effective and high-quality procurement, always source from reliable suppliers.