In the intricate world of organic synthesis, having access to reliable and versatile building blocks is fundamental for innovation. 3-Ethoxy-4-methoxybenzaldehyde, identified by its CAS number 1131-52-8, stands out as such a compound. Its unique aromatic structure, featuring both ethoxy and methoxy substituents alongside an aldehyde group, makes it a highly sought-after intermediate for chemists looking to construct complex molecular architectures.

The Chemical Profile of 3-Ethoxy-4-methoxybenzaldehyde
This fine chemical typically presents as white to yellow crystals with a high purity level, often exceeding 99%. Its melting point of approximately 51°C and its solubility in common organic solvents like methanol facilitate its handling and reaction in various synthetic protocols. The aldehyde functionality is particularly reactive, enabling a wide range of derivatization reactions, including condensations, oxidations, and reductions, while the substituted benzene ring offers sites for further electrophilic or nucleophilic aromatic substitution.

Applications Beyond Pharmaceuticals
While its role as a pharmaceutical intermediate, particularly for Apremilast, is well-established, the utility of 3-Ethoxy-4-methoxybenzaldehyde extends further into general organic synthesis. Researchers leverage it for creating novel compounds with potential applications in material science, fine chemicals, and even fragrances, owing to its aromatic nature. Its incorporation into polymer formulations, for instance, can impart desirable properties such as enhanced thermal stability or specific optical characteristics. For academic and industrial laboratories engaged in method development or custom synthesis, sourcing this compound reliably is crucial.

Procuring 3-Ethoxy-4-methoxybenzaldehyde: A Supplier's Perspective
When seeking to buy 3-Ethoxy-4-methoxybenzaldehyde for your synthesis projects, partnering with a reputable chemical supplier or manufacturer is key. Look for companies that can guarantee consistent product quality, offer detailed technical specifications, and provide flexible packaging solutions to meet varying scale requirements, from laboratory research to pilot plant production. Prioritizing suppliers who demonstrate a strong understanding of chemical synthesis and can provide timely delivery from established production bases, such as those in China, will streamline your procurement process. Requesting samples and comparing pricing from multiple manufacturers can also lead to cost savings without compromising on quality.

Integrating into Synthesis Strategies
The aldehyde group on 3-Ethoxy-4-methoxybenzaldehyde makes it an excellent starting material for Wittig reactions, Knoevenagel condensations, and reductive aminations, all common transformations in building complex organic molecules. Its substituted aromatic ring can also be further functionalized. For example, exploring reactions that target the ethoxy or methoxy groups, or the aromatic core itself, can unlock diverse synthetic pathways. A consistent supply from a trusted manufacturer ensures that these synthetic strategies can be executed without interruption.