The field of organic synthesis is constantly evolving, driven by the demand for novel molecules with specific functionalities. Intermediates like (R)-3-Hydroxymethylpiperazine-1-carboxylate (CAS 278788-66-2) play a pivotal role in this advancement. As a chiral building block, this piperazine derivative offers unique structural features that make it invaluable for creating complex organic compounds, particularly within pharmaceutical research and development. Understanding its properties and synthetic potential is key for chemists aiming to innovate.

The Chemical Profile of a Key Intermediate

(R)-3-Hydroxymethylpiperazine-1-carboxylate is characterized by its piperazine ring, a hydroxymethyl group, and a tert-butyl carbamate protecting group. This combination of functional groups provides multiple reaction sites. The chiral center at the 3-position of the piperazine ring is particularly significant, allowing for the stereoselective synthesis of enantiomerically pure target molecules. Its relatively stable nature, combined with a purity often exceeding 95%, makes it a dependable choice for synthesis planning. When you need to buy this intermediate, specifying its CAS number ensures you obtain the correct isomer.

Applications in Advanced Synthesis

This compound's utility extends across various synthetic pathways. It can be readily functionalized at the amine nitrogen, the hydroxyl group, or through reactions involving the piperazine ring itself. Chemists often employ it in:

  • Peptide Synthesis: As a modified amino acid analog.
  • Drug Discovery: As a core scaffold for synthesizing novel drug candidates, particularly those targeting G-protein coupled receptors or enzyme inhibition.
  • Combinatorial Chemistry: To generate libraries of related compounds for high-throughput screening.
  • Asymmetric Synthesis: Leveraging its inherent chirality to control the stereochemistry of newly formed bonds.

Manufacturers and suppliers offer this intermediate to facilitate these research efforts. By partnering with a reliable supplier, researchers can ensure a consistent supply of this critical component, enabling seamless progression from early-stage research to scale-up. When looking to purchase, consider manufacturers in China, as they often provide a good balance of quality and cost-effectiveness for such specialized organic synthesis intermediates.