The synthesis of pharmaceutical compounds is a highly specialized field, where the quality and availability of precursor molecules directly influence the success of drug development and manufacturing. Within the realm of antiviral medications, Oseltamivir stands out as a vital therapeutic agent. Its efficient synthesis relies heavily on specific chemical intermediates, among which (3R,4R,5S)-Ethyl 4-(N-(tert-butyl)acetamido)-5-(diallylamino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate hydrochloride, identified by CAS number 651324-08-2, plays a pivotal role.

This article aims to shed light on the significance of CAS 651324-08-2 in the Oseltamivir synthesis pathway. For pharmaceutical manufacturers and R&D scientists, understanding the properties and sourcing of this intermediate is not just a matter of chemical precision but also of supply chain integrity and cost-effectiveness. We will explore why this particular ethyl ester monohydrochloride is so crucial and what factors are important when looking to buy or source it.

The structure of CAS 651324-08-2 is meticulously designed to facilitate the subsequent chemical transformations leading to the active Oseltamivir molecule. The stereochemical configuration and functional groups present in this intermediate are essential for directing the synthesis towards the desired enantiomer, thereby ensuring the drug's therapeutic efficacy and minimizing potential side effects from unwanted isomers. Therefore, the purity and precise stereochemistry of this compound are non-negotiable requirements for any pharmaceutical manufacturer.

Key considerations for sourcing CAS 651324-08-2 include:

  • Stereochemical Purity: Beyond standard chemical purity, the enantiomeric purity of the intermediate is critical. Manufacturers must ensure their synthesis processes maintain the correct R/S configurations as specified.
  • Supplier Expertise: Partnering with a manufacturer or supplier with proven expertise in complex organic synthesis and pharmaceutical intermediates is vital. This expertise often translates to better quality control and consistency.
  • Analytical Data: Comprehensive analytical documentation, including NMR, HPLC, and potentially chiral analysis, should be readily available from the supplier. This data confirms the identity, purity, and stereochemistry of the product.
  • Batch Consistency: For production runs, maintaining consistency across different batches of the intermediate is paramount to avoid variations in the final drug product. Reliable suppliers will have robust quality management systems in place.
  • Cost and Availability: Balancing quality with cost is a constant challenge. Exploring options from various suppliers, particularly those in major chemical manufacturing hubs like China, can provide access to competitive pricing. Ensuring reliable availability for planned production schedules is also key.

As a dedicated supplier of pharmaceutical intermediates, we understand the stringent demands of the Oseltamivir synthesis process. We offer Ethyl Ester Monohydrochloride (CAS 651324-08-2) that adheres to high-quality standards, backed by thorough analytical data. Our commitment as a manufacturer and supplier is to provide the pharmaceutical industry with a dependable source for this critical intermediate, ensuring that your production lines run smoothly and your final products meet the highest therapeutic standards. We invite you to contact us for pricing inquiries and to discuss how we can meet your specific requirements for this vital compound.