The pharmaceutical industry relies heavily on a diverse range of chemical intermediates to synthesize active pharmaceutical ingredients (APIs) and develop life-saving medications. Among these critical building blocks is 2-(2,4-Diaminophenoxy)ethanol dihydrochloride, identified by its CAS number 66422-95-5. For R&D scientists and procurement specialists, understanding the sourcing and quality aspects of such intermediates is paramount. This article explores the importance of this compound and provides guidance on how to buy it from reputable suppliers, with a focus on manufacturers in China.

Understanding 2-(2,4-Diaminophenoxy)ethanol Dihydrochloride

2-(2,4-Diaminophenoxy)ethanol dihydrochloride, with the molecular formula C8H14Cl2N2O2, serves as a versatile intermediate in organic synthesis. While it is widely recognized for its application in hair dye formulations due to its oxidative properties, its chemical structure also makes it valuable in pharmaceutical research and development. The presence of amino and hydroxyl groups offers multiple reaction sites for further chemical modifications, enabling the creation of complex molecular architectures required for certain drug compounds. When considering its use as a pharmaceutical intermediate, exceptional purity is non-negotiable. A high assay, typically ≥99.5%, alongside controlled levels of heavy metals and residual solvents, ensures that it meets the stringent standards required for pharmaceutical applications.

Synthesis and Quality Control

The synthesis of 2-(2,4-Diaminophenoxy)ethanol dihydrochloride often involves multi-step chemical processes, starting from readily available raw materials. The manufacturing process must be meticulously controlled to achieve the desired purity and minimize by-products. Quality control is therefore a critical aspect for any pharmaceutical intermediate supplier. This includes rigorous analytical testing at various stages of production. Parameters such as melting point (222-224°C), appearance (pale grey powder), assay, and impurity profiles are routinely checked. For procurement managers, requesting comprehensive Certificates of Analysis (CoA) is a standard practice to verify product quality before making a purchase decision. Reliable manufacturers will provide detailed documentation to support their product claims.

Sourcing from China: Opportunities and Considerations

China has become a leading global supplier of pharmaceutical intermediates, offering both cost-effectiveness and a wide range of products. When you need to buy 2-(2,4-Diaminophenoxy)ethanol dihydrochloride, exploring manufacturers in China can be highly beneficial. However, it is crucial to partner with established companies that have a strong reputation for quality and compliance. Look for suppliers who are well-versed in international shipping regulations and have experience exporting to your region. Sending a clear inquiry, including your specific needs like 'pharmaceutical grade 2-(2,4-Diaminophenoxy)ethanol dihydrochloride' and desired quantity, will help in identifying suitable partners. Many Chinese chemical manufacturers are equipped with advanced production facilities and adhere to international quality standards, making them ideal sources.

Pricing and Procurement Best Practices

When inquiring about pricing for CAS 66422-95-5, it's advisable to request quotes from several suppliers to compare costs and terms. Factors influencing the price include purity, order volume, and packaging requirements. For bulk purchases, negotiating pricing directly with a manufacturer can yield significant cost savings. Always clarify payment terms, delivery lead times, and any minimum order quantities (MOQ). For research and development purposes, smaller quantities might be available for testing, but for commercial production, ensuring a scalable supply is key. A well-formulated inquiry often includes: 'Inquiry for bulk purchase of 2-(2,4-Diaminophenoxy)ethanol dihydrochloride (CAS 66422-95-5), 99.5% minimum purity, delivered to [Your Country]. Please provide a quote and lead time.'

Conclusion

2-(2,4-Diaminophenoxy)ethanol dihydrochloride is a vital intermediate with significant potential in pharmaceutical synthesis and cosmetic applications. For businesses requiring this compound, understanding its quality requirements and leveraging the strengths of global suppliers, particularly from China, is essential. By focusing on purity, reliable manufacturing practices, and clear communication during the procurement process, companies can effectively source this critical chemical intermediate.