The pharmaceutical industry constantly seeks novel molecular scaffolds and reactive intermediates to synthesize innovative drug candidates. Heterocyclic compounds, with their diverse structural possibilities and inherent biological activities, are cornerstones of modern medicinal chemistry. Among these, nitrogen-containing heterocycles like phenanthrolines have attracted significant interest due to their ability to interact with biological targets and their utility as chelating agents. 1,10-Phenanthroline-5-carbaldehyde (CAS: 91804-75-0) stands out as a particularly valuable pharmaceutical intermediate, offering a unique combination of a rigid phenanthroline backbone and a reactive aldehyde group.

The Value of Phenanthroline Derivatives in Drug Discovery

Phenanthroline structures are found in various biologically active molecules and have been explored for a range of therapeutic applications, including anticancer agents, antivirals, and DNA intercalators. The presence of the aldehyde functionality in 1,10-Phenanthroline-5-carbaldehyde allows for straightforward chemical transformations. It can participate in condensation reactions, reductive aminations, and other coupling reactions to build more complex drug-like molecules. This makes it an attractive starting material for medicinal chemists designing new synthetic routes.

Sourcing High-Quality 91804-75-0 for Pharma R&D

For pharmaceutical companies and contract research organizations (CROs), the reliable supply of high-purity chemical intermediates is non-negotiable. 1,10-Phenanthroline-5-carbaldehyde, typically available as a white powder with a minimum purity of 97%, is crucial for ensuring the integrity and efficacy of synthesized compounds. Procurement managers often look to established chemical manufacturers and suppliers, particularly those based in China, known for their robust production capabilities and competitive pricing. When you need to buy this intermediate, ensure your supplier can provide comprehensive documentation and consistent quality for your sensitive drug discovery programs.

Chemical Properties and Synthesis Applications

With a molecular formula of C13H8N2O and a molecular weight of 208.21500, 1,10-Phenanthroline-5-carbaldehyde is a well-characterized compound. Its solid form (white powder) and straightforward handling characteristics further enhance its appeal in laboratory settings. The ability to purchase 91804-75-0 in various quantities, from research-scale grams to bulk production kilograms, allows seamless integration into both early-stage discovery and later-stage development phases. Reliable suppliers can often facilitate custom synthesis requests for specific purity grades or derivatives.

The strategic use of intermediates like 1,10-Phenanthroline-5-carbaldehyde empowers pharmaceutical researchers to explore novel chemical space and develop next-generation therapeutics. By partnering with experienced chemical suppliers, the journey from laboratory synthesis to potential clinical application becomes more efficient and reliable.