The pharmaceutical industry relies heavily on a diverse array of chemical intermediates to synthesize life-saving drugs and innovative therapies. Among these critical building blocks, pyridine derivatives play a significant role due to their versatile chemical reactivity and presence in many biologically active compounds. (5-Methylpyridin-3-yl)methanol (CAS 102074-19-1) stands out as a valuable pharmaceutical intermediate, offering a unique structural motif for drug discovery and development. This article explores its importance and provides guidance for R&D professionals and procurement specialists looking to buy (5-Methylpyridin-3-yl)methanol.

Understanding (5-Methylpyridin-3-yl)methanol in Drug Development

(5-Methylpyridin-3-yl)methanol, identified by its CAS number 102074-19-1, is a pyridine derivative with a hydroxymethyl group at the 3-position and a methyl group at the 5-position. Its molecular formula is C7H9NO, with a molecular weight of 123.15 g/mol. This structure makes it a versatile starting material or intermediate in the synthesis of various Active Pharmaceutical Ingredients (APIs). Researchers often seek this compound for its potential to introduce specific pharmacophoric elements into candidate drug molecules, influencing their binding affinity, metabolic stability, and overall pharmacokinetic profile. When sourcing for pharmaceutical applications, inquiring about the (5-methylpyridin-3-yl)methanol price from a reputable manufacturer is a key step.

Key Applications and Synthesis Pathways:

  • Drug Discovery and Lead Optimization: (5-Methylpyridin-3-yl)methanol can be functionalized further to create a library of compounds for screening against various biological targets. Its pyridine ring system is a common scaffold in many approved drugs.
  • Intermediate for APIs: It serves as a crucial intermediate in multi-step synthesis routes for specific APIs. For instance, it can be oxidized, halogenated, or coupled to other molecular fragments to build complex drug structures.
  • Research and Development: In academic and industrial R&D settings, it's used to explore novel chemical entities and synthetic methodologies.

The synthesis of (5-Methylpyridin-3-yl)methanol itself often involves reduction reactions of ester precursors, such as methyl 5-methylnicotinate. Companies that specialize in fine chemical manufacturing, particularly those operating as a (5-methylpyridin-3-yl)methanol supplier, can provide this compound at various purity grades suitable for pharmaceutical research and production. Leveraging a direct manufacturer relationship, especially in regions like China, can offer significant advantages in terms of cost and consistent supply.

Procurement Considerations for Pharmaceutical Buyers:

When you intend to purchase (5-Methylpyridin-3-yl)methanol for pharmaceutical applications, rigorous supplier vetting is essential. Key considerations include:

  • cGMP Compliance: For later-stage development or commercial production, ensure the supplier can meet current Good Manufacturing Practices (cGMP) standards.
  • Purity and Impurity Profiling: Beyond basic purity, understand the impurity profile of the supplied intermediate. This is critical for regulatory submissions.
  • Supply Chain Security: A stable supply chain is vital. Work with a (5-methylpyridin-3-yl)methanol supplier that demonstrates robust production capabilities and has contingency plans.
  • Regulatory Support: The supplier should be able to provide necessary documentation to support your regulatory filings.

In conclusion, (5-Methylpyridin-3-yl)methanol is a valuable pharmaceutical intermediate that facilitates the creation of new medicines. By partnering with a trusted manufacturer and carefully considering factors like purity, price, and regulatory compliance, researchers and companies can effectively leverage this compound in their drug development endeavors.