For chemists and chemical engineers, a deep understanding of a chemical intermediate's properties is fundamental to optimizing synthetic routes and achieving desired outcomes. Phenylhydrazine Hydrochloride (CAS 59-88-1) is a widely used fine chemical, recognized for its role in various synthetic transformations. This article explores its key chemical characteristics and provides guidance on its synthesis applications.

Phenylhydrazine Hydrochloride, with the molecular formula C6H9ClN2 and molecular weight of 144.60, typically presents as a White to light yellow or pinkish-beige Fine Crystalline Powder. Its melting point is approximately 250-254 °C, often accompanied by decomposition, indicating its thermal sensitivity. The solubility in water is rated at 50 g/L at 20 °C, and it exhibits a slightly acidic pH of 2.6-2.9 in a 50g/l aqueous solution. These properties are essential for designing reaction conditions, choosing appropriate solvents, and predicting reactivity.

The primary utility of Phenylhydrazine Hydrochloride in synthesis lies in its nucleophilic character. It is a cornerstone reagent for the Fischer indole synthesis, a method for constructing indole rings – a common motif in pharmaceuticals, agrochemicals, and natural products. By reacting with aldehydes or ketones under acidic conditions, it forms phenylhydrazones, which then cyclize and eliminate ammonia to yield the indole. For researchers looking to buy Phenylhydrazine Hydrochloride for these applications, understanding this reaction mechanism is key.

Beyond indole synthesis, Phenylhydrazine Hydrochloride serves as a valuable intermediate for various dyes and in specific biochemical research applications. Its ability to form derivatives that can be further modified makes it a flexible building block for organic chemists. When sourcing this compound, prioritizing a reliable chemical supplier that guarantees high purity and consistent product specifications is crucial. Enquiring about the Phenylhydrazine Hydrochloride price from a trusted manufacturer, especially for bulk orders, ensures cost-effectiveness for your projects.

In practice, Phenylhydrazine Hydrochloride is handled with care due to its chemical reactivity. Proper storage conditions and adherence to safety protocols are essential. By leveraging its well-defined chemical properties and sourcing from reputable manufacturers, chemists can effectively utilize Phenylhydrazine Hydrochloride to drive innovation in their synthetic endeavors.