In the relentless pursuit of novel anticancer therapies, researchers constantly seek potent and selective molecular targets. One such critical target is the Insulin-like Growth Factor-1 Receptor (IGF-1R), a transmembrane tyrosine kinase receptor that plays a pivotal role in cell proliferation, survival, and migration. Aberrant activation of the IGF-1R pathway is frequently observed in various human cancers, making it an attractive target for therapeutic intervention. This is where Picropodophyllotoxin, a naturally derived lignan, emerges as a compound of significant interest.

Picropodophyllotoxin (CAS 477-47-4), also known as Picropodophyllin, is a potent and selective inhibitor of IGF-1R. Its mechanism of action is distinct; it acts as a non-competitive inhibitor with respect to ATP, directly impacting the receptor's autophosphorylation. This specific inhibition has profound implications for controlling cancer cell growth. Studies have demonstrated that Picropodophyllotoxin exhibits significant antiproliferative activity across a wide range of cancer cell lines, with IC50 values often in the nanomolar to low micromolar range. Furthermore, it has shown promising antiangiogenic properties, which are crucial for limiting tumor vascularization and thus inhibiting tumor growth and metastasis.

For researchers and procurement managers in the pharmaceutical and biotechnology sectors, sourcing high-quality Picropodophyllotoxin is paramount for the success of their projects. As a leading manufacturer and supplier of fine chemicals in China, we specialize in providing Picropodophyllotoxin (CAS 477-47-4) with purity exceeding 97%. Our commitment to quality assurance ensures that our clients receive a reliable reagent for their in vitro and in vivo studies. Whether you are exploring its effects on cell cycle regulation, signaling pathway modulation, or its potential as a therapeutic agent, our product is designed to meet your rigorous scientific standards. We understand the importance of a stable supply chain, and we are dedicated to ensuring consistent availability for our clients who wish to buy this crucial compound.

The applications of Picropodophyllotoxin extend beyond direct therapeutic use; it serves as an invaluable tool in fundamental research. Scientists utilize it to dissect the complex IGF-1R signaling cascade, understand resistance mechanisms, and identify synergistic combinations with other anti-cancer agents. Its ability to reduce phosphorylated Akt (pAkt) and phosphorylated ERK1/2 (pErk1/2), key downstream signaling molecules, provides further insight into its cellular impact. If your research requires a high-purity IGF-1R inhibitor, we are your trusted source to purchase Picropodophyllotoxin.

We encourage you to reach out to us for the latest price and to request a sample of our Picropodophyllotoxin. As a dedicated supplier in China, we are committed to supporting your research endeavors with premium-grade chemicals and exceptional customer service. Invest in quality, reliability, and scientific advancement by choosing us as your partner for Picropodophyllotoxin.