In the dynamic field of organic chemistry, the synthesis of organoboron compounds has revolutionized many areas, from pharmaceuticals to material science. At the heart of this revolution lies Pinacol (CAS 76-09-5), a simple yet exceptionally important diol that serves as a key precursor for some of the most widely used boronic acid reagents. As a dedicated manufacturer and supplier, we recognize the critical role Pinacol plays and are committed to providing high-purity material to support these essential synthetic transformations.

Pinacol: The Foundation for Boronic Acid Chemistry

Pinacol, also known as 2,3-Dimethyl-2,3-butanediol, is a white solid that readily reacts with boron halides or other boron sources to form stable cyclic boronates. The most prominent of these are:

  • Bis(pinacolato)diboron (B2pin2): Synthesized from Pinacol and diboron compounds, B2pin2 is the go-to reagent for Miyaura borylation, a method that introduces the pinacol boronate ester group onto aryl and vinyl halides and pseudohalides. These pinacol boronate esters are stable, easy to handle, and are the direct precursors to aryl and vinyl boronic acids, which are vital for Suzuki-Miyaura cross-coupling reactions.
  • Pinacolborane (HBpin): Prepared by reacting Pinacol with borane reagents, HBpin is a valuable reagent for the hydroboration of alkenes and alkynes. This reaction adds the pinacol boronate ester group across the double or triple bond, forming organoboranes that can be further functionalized.

The stability and ease of handling of these Pinacol-derived boronate esters compared to their free boronic acid counterparts make them the preferred choice for many synthetic chemists. The 99% purity of our supplied Pinacol ensures the efficient and clean synthesis of these critical boron reagents.

Why Choose Our Pinacol for Boronic Acid Synthesis?

For R&D scientists and procurement managers working with organoboron chemistry, securing a consistent and high-quality source of Pinacol is essential. As a leading manufacturer and supplier from China, we offer:

  • Guaranteed High Purity: Our Pinacol is guaranteed to be 99% pure, ensuring efficient conversion to B2pin2 and HBpin with minimal by-products.
  • Consistent Supply: We maintain robust production capacities to meet the demands for bulk quantities, providing a reliable supply chain for your ongoing projects.
  • Competitive Pricing: We offer cost-effective solutions for sourcing Pinacol, allowing you to optimize your research and development budgets.

Investing in high-quality Pinacol is an investment in the success of your organoboron chemistry. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to being your trusted partner for this essential chemical intermediate. If you are looking to buy Pinacol to advance your synthesis of boronic acids and their derivatives, please contact us for a quote and to discuss your specific needs.