While D-Lysine (CAS: 923-27-3) itself is a crucial amino acid for specialized research, its polymeric form, poly-D-lysine (PDL), has carved out significant niches in cell culture and drug delivery systems. As a manufacturer and supplier of high-purity D-Lysine from China, we recognize the importance of understanding the applications of its derivatives. PDL's unique characteristics make it an indispensable tool for life science researchers.

Poly-D-lysine is a synthetic polymer composed of repeating D-Lysine units. Unlike its naturally occurring counterpart, poly-L-lysine, PDL exhibits remarkable stability against enzymatic degradation by cellular proteases. This inherent resistance makes it a preferred choice for applications requiring a stable, non-degradable substrate or carrier.

Key applications of Poly-D-Lysine include:

  • Cell Culture Substrates: PDL is widely used to coat cell culture plates and flasks. Its positive charge promotes the adhesion and growth of various cell types, particularly primary neurons and other sensitive cells that may not adhere well to standard tissue culture plastic. This enhancement is critical for researchers studying cell behavior, neurobiology, and developmental biology. When sourcing materials for advanced cell culture, buying high-quality PDL derived from pure D-Lysine is essential for reproducible results.
  • Drug Delivery Systems: The cationic nature of PDL makes it an excellent candidate for developing polymeric drug delivery systems. It can bind to negatively charged nucleic acids (like DNA or RNA) to form polyplexes for gene delivery, or it can encapsulate small-molecule drugs. Its biocompatibility and stability allow for controlled release and improved cellular uptake. Researchers often explore these D-Lysine-based polymers to create novel therapeutic formulations.
  • Gene Transfection: PDL can be used as a component in non-viral gene delivery systems, facilitating the uptake of plasmid DNA into cells. Its ability to condense genetic material and interact with cell membranes aids in the transfection process, making it valuable in molecular biology research and potentially in gene therapy development.

The quality of the D-Lysine monomer directly impacts the properties and performance of the resulting poly-D-lysine. As a dedicated manufacturer, we ensure that our D-Lysine (CAS 923-27-3) is of the highest purity, providing a reliable foundation for producing high-quality PDL. For researchers and companies looking to purchase PDL or its precursor, D-Lysine, partnering with a trusted China supplier like us ensures consistent product quality, competitive pricing, and a stable supply chain.

We are committed to supporting your scientific endeavors by providing the essential building blocks for your research. If you require D-Lysine for synthesizing PDL or for other biochemical applications, please reach out to us to discuss your needs. We aim to be your premier source for high-quality D-Lysine and its derivatives.