For procurement professionals in the chemical and pharmaceutical sectors, identifying reliable sources for key intermediates is a critical function. 4-Hydrazinobenzenesulfonamide (CAS 4392-54-5) is one such compound, primarily sought after for its role in the synthesis of Celecoxib. This guide aims to provide practical advice for procurement managers looking to purchase this essential chemical, emphasizing quality, supplier selection, and cost-effectiveness.

Understanding the Demand Driver: Celecoxib Synthesis

The primary driver for the demand of 4-Hydrazinobenzenesulfonamide is its essential function as an intermediate in the production of Celecoxib, a widely used NSAID. For pharmaceutical manufacturers, securing a stable supply chain for this compound directly impacts their ability to meet market demand for Celecoxib. Therefore, a robust procurement strategy is essential.

Key Procurement Considerations

When initiating the purchase of 4-Hydrazinobenzenesulfonamide, procurement professionals should focus on the following:

  1. Product Quality: The chemical assay, typically ≥98.0%, is paramount. Always request and review the Certificate of Analysis (COA) to confirm purity and identify any critical impurities. The physical form (off-white to light beige powder) and packaging (e.g., 25 kg drums) should also be confirmed.
  2. Supplier Identification: The market offers numerous suppliers, with a concentration of manufacturers in China. It is advisable to work with established manufacturers and distributors who have a proven track record in the chemical or pharmaceutical intermediate sector. Consider suppliers who can provide comprehensive documentation, including Material Safety Data Sheets (MSDS).
  3. Price Negotiation and Quotation: Obtaining multiple quotes is a standard procurement practice. Engage directly with manufacturers to understand their pricing structures, especially for bulk purchases. Factors influencing price include raw material costs, production volume, and global market demand. Asking for a quote is the first step to understanding the investment required.
  4. Supply Chain Reliability: Beyond price, the consistency and reliability of the supply are crucial. Evaluate potential suppliers based on their production capacity, lead times, and logistics capabilities. Understanding their ability to meet your required order volumes and delivery schedules is essential for avoiding production disruptions.
  5. Regulatory Compliance: For pharmaceutical applications, ensure that the intermediate meets relevant regulatory standards and that the supplier can provide any necessary supporting documentation for your filings.

Navigating the Chinese Market for 4-Hydrazinobenzenesulfonamide

China remains a dominant force in the global chemical manufacturing landscape. Many manufacturers there specialize in pharmaceutical intermediates like 4-Hydrazinobenzenesulfonamide, often offering competitive pricing. Procurement managers looking to buy from China should conduct thorough due diligence, verifying supplier credentials and ensuring compliance with international quality and safety standards. Building a strong relationship with a trusted Chinese manufacturer can lead to long-term supply advantages.

In conclusion, the procurement of 4-Hydrazinobenzenesulfonamide (CAS 4392-54-5) requires a strategic approach. By prioritizing quality, vetting suppliers thoroughly, understanding market pricing, and ensuring supply chain continuity, procurement professionals can effectively secure this vital intermediate, supporting the uninterrupted production of essential pharmaceuticals like Celecoxib.