Procurement of critical chemical intermediates is a cornerstone of success in the pharmaceutical industry. 1-Benzylpiperidine-4-carbonitrile (CAS: 62718-31-4) is a highly sought-after compound, serving as a vital building block in the synthesis of numerous pharmaceutical agents. This guide is designed to assist procurement managers in navigating the process of sourcing this essential intermediate, ensuring quality, cost-effectiveness, and supply chain reliability.

Understanding the Value of 1-Benzylpiperidine-4-carbonitrile

1-Benzylpiperidine-4-carbonitrile is an organic compound with a molecular formula C₁₃H₁₆N₂. It is predominantly used as an intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly those designed for central nervous system (CNS) disorders and pain management. Its structure allows for diverse chemical modifications, making it adaptable for a wide range of drug development pathways. The compound's significance is amplified by its role in the creation of potent analgesics and compounds with potential antipsychotic or neuroprotective activities.

Key Procurement Factors

When sourcing 1-Benzylpiperidine-4-carbonitrile, procurement professionals should prioritize the following:

  • Supplier Qualification: Identify manufacturers with a proven track record in producing high-purity pharmaceutical intermediates. Look for suppliers who can provide detailed Certificates of Analysis (CoA) confirming purity levels (typically >97%), spectral data (NMR, MS, IR), and compliance with relevant quality standards. Establishing relationships with trusted pharmaceutical intermediate suppliers is crucial for long-term project success.
  • Quality Assurance: Verify that the supplier adheres to stringent quality control measures throughout the manufacturing process. This ensures batch-to-batch consistency, which is critical for reproducible research and scaled-up production. Inquire about their quality management systems and any relevant certifications.
  • Pricing and Cost-Effectiveness: Obtain quotes from multiple suppliers to compare the 1-Benzylpiperidine-4-carbonitrile price. Consider bulk purchase discounts and the total cost of ownership, which includes factors like shipping, lead times, and potential costs associated with quality issues. Engaging with manufacturers directly can often lead to more competitive pricing.
  • Supply Chain Stability: Ensure the supplier has adequate production capacity and robust logistics to meet your demand projections. A stable supply chain minimizes the risk of disruptions in your R&D or manufacturing timelines. Manufacturers in China and other global hubs are often key sources for such intermediates.
  • Technical Support: A responsive supplier that can provide technical assistance, answer queries regarding synthesis, handling, and storage, and offer safety data (MSDS) adds significant value.

Applications Driving Demand

The demand for 1-Benzylpiperidine-4-carbonitrile is sustained by its critical role in the development of:

  • Analgesics: As a precursor to opioid analgesics, it supports the production of essential pain management medications.
  • CNS Agents: Its structure is vital for developing compounds targeting neurological and psychiatric conditions.
  • Advanced Therapies: It serves as a precursor for novel therapeutic agents in areas like cancer treatment (PDT, BNCT).

Conclusion: Strategic Sourcing for Pharmaceutical Success

Effective procurement of 1-Benzylpiperidine-4-carbonitrile requires a strategic approach, focusing on quality, supplier reliability, and cost. By diligently evaluating potential suppliers and understanding the compound's critical applications, procurement managers can secure a vital intermediate that fuels pharmaceutical innovation and supports the development of life-saving medicines.