For procurement managers in the pharmaceutical sector, securing a reliable supply of high-quality chemical intermediates at competitive prices is a constant challenge. One such crucial compound is Ethyl 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester, identified by CAS 503614-91-3. This particular chemical, often noted as an Apixaban Ethyl Ester Impurity, is an indispensable component in the synthesis of essential medications. This guide focuses on how procurement professionals can effectively buy this vital intermediate from China manufacturers and suppliers.

Understanding Your Needs: Quality and Quantity

Before initiating a search, it is critical to clearly define your requirements. For CAS 503614-91-3, this means specifying the desired purity level, expected order quantity (from research grams to industrial tons), and any specific analytical documentation required, such as a Certificate of Analysis (CoA) detailing results from HPLC, NMR, and Mass Spectrometry. As a pharmaceutical intermediate, high purity is non-negotiable. Companies looking to purchase this compound should prioritize suppliers who demonstrate stringent quality control and regulatory compliance. Your inquiry should clearly state these needs to potential vendors.

Identifying Reliable China Manufacturers and Suppliers

China boasts a robust and expansive chemical manufacturing industry. To find the right partner for CAS 503614-91-3, procurement managers should target companies specializing in pharmaceutical intermediates and fine chemicals. Look for established companies with a proven history of supplying to the global pharmaceutical market. Utilizing industry directories, trade shows, and online B2B platforms can help in identifying potential vendors. When you find a promising supplier, don't hesitate to request detailed product specifications, manufacturing site information, and a sample for internal evaluation. The initial engagement can often determine the long-term viability of the relationship, especially when focusing on price and delivery.

Negotiating Price and Terms

One of the primary drivers for sourcing from China is often the competitive price. However, simply choosing the lowest bid can be detrimental to quality. Procurement managers should seek a balance between cost-effectiveness and assured quality. When requesting quotes from multiple manufacturers, provide them with your exact specifications and quantity requirements. Be prepared to discuss payment terms (e.g., T/T, L/C) and Incoterms (e.g., FOB, CIF, EXW) to ensure clarity and manage logistical costs. Building a good rapport with the sales team of a Chinese chemical company can often lead to more favorable negotiations and a better overall understanding of the market dynamics affecting the final price.

Logistics and Compliance

Ensuring smooth delivery of your pharmaceutical intermediate is crucial. Confirm the supplier's capabilities in international shipping and their understanding of import regulations in your country. For a chemical like CAS 503614-91-3, you might need to consider specific handling and storage requirements during transit. A reliable supplier will have experience in navigating these complexities and can provide assistance with necessary documentation. By thoroughly vetting potential suppliers and clearly communicating your needs, procurement managers can successfully purchase high-quality CAS 503614-91-3 from China, securing a vital component for their pharmaceutical manufacturing processes.