For professionals in the pharmaceutical sector, the procurement of chemical intermediates is a critical function that underpins the entire manufacturing process. The compound 4-Chlorobutanal Dimethyl Acetal, identified by CAS Number 29882-07-3, is a prime example of such an essential intermediate, specifically for the synthesis of Rizatriptan Benzoate, a key medication for managing migraines. This guide aims to assist procurement managers and R&D scientists in making informed decisions when sourcing this vital chemical.

Understanding the specifications of 4-Chlorobutanal Dimethyl Acetal is the first step. As a colorless transparent liquid, its purity is typically guaranteed at ≥98.0%, a standard crucial for pharmaceutical applications. Its molecular formula C6H13ClO2 and molecular weight of 152.619 are important technical details. When looking to buy, it’s beneficial to know its physical properties like boiling point (168.3°C at 760 mmHg) and flash point (42.9°C) for safe handling and process integration. Reliable suppliers will provide comprehensive documentation, including Certificates of Analysis (CoA), to verify these parameters.

The primary application for 4-Chlorobutanal Dimethyl Acetal is its role as a precursor in the synthesis of Rizatriptan Benzoate (CAS: 145202-66-0). This means that sourcing decisions must prioritize quality and consistency. Pharmaceutical manufacturers should seek out suppliers who can demonstrate a robust quality management system, potentially including GMP compliance. Investigating manufacturers and suppliers, particularly those based in regions with strong chemical production infrastructure like China, can offer advantages in terms of cost and availability. Competitive pricing is a significant factor, but it should never come at the expense of product integrity.

For procurement managers, building strong relationships with trusted suppliers is key. This involves not only securing competitive pricing for 4-Chlorobutanal Dimethyl Acetal but also ensuring a reliable supply chain. Considerations should include the supplier's production capacity, packaging options (e.g., 25 kg drums), and their ability to provide timely deliveries. Engaging with manufacturers who offer technical support and are responsive to inquiries will streamline the procurement process and contribute to the overall efficiency of Rizatriptan Benzoate production. Ultimately, a well-executed sourcing strategy for this intermediate directly impacts the quality and availability of the final medication.