For pharmaceutical manufacturers focusing on anticoagulant therapies, the consistent and high-quality supply of key intermediates is paramount. One such critical component in the synthesis of Edoxaban, a widely prescribed Factor Xa inhibitor, is Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride (CAS: 1243308-37-3). Understanding how to procure this chemical efficiently can significantly impact production timelines and cost-effectiveness. This guide offers insights for procurement managers and R&D scientists seeking reliable sources, particularly from China.

Understanding the Importance of Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate Hydrochloride

Edoxaban, known for its role in preventing stroke and systemic embolism in patients with atrial fibrillation, requires precise chemical building blocks for its synthesis. Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride, typically appearing as a white to off-white crystalline powder with an assay of ≥98.0%, serves as a fundamental precursor. Its chemical structure and purity directly influence the yield and quality of the final Active Pharmaceutical Ingredient (API).

Key Considerations for Procurement Managers

When sourcing this vital intermediate, procurement managers should prioritize:

  1. Supplier Reliability: Look for manufacturers with a proven track record and robust quality control systems. A reputable manufacturer in China can offer stable production capacity and consistent product quality.
  2. Purity and Specifications: Always verify that the intermediate meets the required assay (≥98.0%) and other specified parameters. Certificates of Analysis (CoA) are essential documentation.
  3. Pricing and Lead Times: Obtaining competitive pricing is crucial for cost management. Simultaneously, understanding the supplier's lead times for production and delivery ensures that your manufacturing schedule is not disrupted. Negotiating a favorable Edoxaban intermediate price is a key objective.
  4. Regulatory Compliance: Ensure that the supplier adheres to relevant Good Manufacturing Practices (GMP) and international quality standards, which is critical for pharmaceutical applications.
  5. Packaging and Storage: Standard packaging, such as 25 kg drums, should be available, along with appropriate storage recommendations to maintain product integrity.

Navigating the Chinese Market for Intermediates

China has emerged as a global hub for chemical manufacturing, including pharmaceutical intermediates. When looking to buy Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride from China, it is beneficial to partner with established companies that possess strong R&D capabilities and a commitment to international quality standards. Many Chinese suppliers offer extensive experience in custom synthesis and large-scale production, making them ideal partners for both R&D and commercial manufacturing.

Finding a Trusted Manufacturer and Supplier

For those in the pharmaceutical sector, identifying a dependable Edoxaban intermediate supplier in China is key to a smooth procurement process. Leading manufacturers can provide not only the product itself but also technical support and documentation necessary for regulatory filings. Engaging with a supplier that can offer consistent quality, competitive pricing, and timely delivery is crucial for success in the highly regulated pharmaceutical industry. When you purchase Edoxaban intermediate for pharmaceutical synthesis, ensure your chosen partner can meet all these demands, guaranteeing the integrity of your Edoxaban API production.