In the demanding world of pharmaceutical manufacturing, the quality and reliability of chemical intermediates are paramount. For companies seeking to develop novel Active Pharmaceutical Ingredients (APIs), sourcing high-purity chiral building blocks is a critical step. One such vital compound is (3S)-3-(tert-Butoxycarbonyl)amino-1-chloro-4-phenyl-2-butanone, identified by its CAS number 102123-74-0. This article aims to guide procurement managers and R&D scientists in understanding the importance of this intermediate and how to effectively source it from reputable manufacturers and suppliers, particularly those based in China.

Understanding the Value of Chiral Intermediates

Chirality, or the property of a molecule being non-superimposable on its mirror image, is a fundamental concept in medicinal chemistry. Many drugs exert their therapeutic effects through specific interactions with biological targets, which often recognize only one enantiomer of a chiral molecule. The incorrect enantiomer can be inactive or, in some cases, harmful. Therefore, intermediates like (3S)-3-(tert-Butoxycarbonyl)amino-1-chloro-4-phenyl-2-butanone, which possess defined stereochemistry, are indispensable for synthesizing enantiomerically pure APIs. Its unique structure, featuring a Boc-protected amine, a chloroketone moiety, and a phenyl group, makes it a versatile precursor for a range of complex organic syntheses.

Key Specifications and Quality Assurance

When looking to buy (3S)-3-(tert-Butoxycarbonyl)amino-1-chloro-4-phenyl-2-butanone, pharmaceutical professionals must pay close attention to key specifications. These typically include purity (often >97%), molecular weight (297.78 g/mol), and molecular formula (C15H20ClNO3). Furthermore, ensuring the chiral integrity of the compound is crucial; the (3S) configuration is vital for its intended use in stereoselective synthesis. Reputable manufacturers will provide a Certificate of Analysis (CoA) with each batch, detailing these critical parameters and confirming the absence of significant impurities.

Sourcing Strategies: Partnering with Chinese Manufacturers

China has emerged as a global powerhouse in chemical manufacturing, offering a vast array of intermediates at competitive prices. For (3S)-3-(tert-Butoxycarbonyl)amino-1-chloro-4-phenyl-2-butanone, partnering with experienced Chinese manufacturers and suppliers can provide significant advantages. These suppliers often possess advanced production capabilities and adhere to international quality standards. When evaluating potential suppliers, it is advisable to look for those with a proven track record, robust quality control systems, and a commitment to customer service.

When you inquire about the price for CAS 102123-74-0, remember to specify your required quantities and any particular quality certifications. Many Chinese chemical manufacturers are equipped to handle both small-scale R&D orders and large-scale industrial production, offering flexible packaging and delivery options. Establishing a strong relationship with a reliable supplier can ensure a consistent and dependable supply chain for this critical pharmaceutical intermediate.

Applications in Pharmaceutical Synthesis

The utility of (3S)-3-(tert-Butoxycarbonyl)amino-1-chloro-4-phenyl-2-butanone extends across various therapeutic areas. Its structure lends itself to the synthesis of compounds targeting viral infections, neurological disorders, and metabolic diseases. As a key building block, it allows chemists to efficiently introduce specific stereocenters and functional groups, thereby streamlining complex multi-step synthetic routes. The Boc protection group is readily removable under mild conditions, facilitating subsequent reactions and protecting the amine functionality during sensitive transformations.

Conclusion

For pharmaceutical manufacturers and researchers, securing a reliable source of high-quality (3S)-3-(tert-Butoxycarbonyl)amino-1-chloro-4-phenyl-2-butanone (CAS 102123-74-0) is fundamental to successful drug development. By understanding the compound's specifications and leveraging the capabilities of leading Chinese manufacturers and suppliers, companies can ensure the consistent procurement of this essential chiral intermediate. Partnering with expert suppliers not only provides access to quality materials but also offers valuable support in navigating the complexities of chemical sourcing, ultimately contributing to faster and more efficient R&D and production cycles. If you are looking to purchase this product, consider reaching out to established manufacturers for competitive pricing and detailed technical information.