As a procurement manager in the pharmaceutical industry, securing high-quality raw materials is paramount. Sacubitril, a crucial intermediate in the synthesis of cardiovascular drugs, demands stringent purity standards. Understanding the critical aspects of sourcing this compound can significantly impact your drug development and manufacturing processes. This guide aims to assist you in identifying reliable manufacturers and suppliers for Sacubitril (CAS 149709-62-6).

Understanding Sacubitril Intermediate (CAS 149709-62-6)

Sacubitril (CAS 149709-62-6) is characterized by its molecular formula C24H29NO5 and a molecular weight of 411.49. It typically appears as a colorless transparent oily liquid, with a purity specification of ≥99%. Its primary application lies in its role as an intermediate for advanced cardiovascular medications, notably as a component in combination therapies for heart failure. For pharmaceutical companies, ensuring the consistent availability of this high-purity intermediate is key to maintaining production schedules and product quality.

Key Considerations When Sourcing Sacubitril

When looking to buy Sacubitril intermediate, several factors warrant close attention:

  • Purity Levels: The '≥99%' purity specification is non-negotiable for pharmaceutical applications. Any deviation can compromise the efficacy and safety of the final drug product. Always request Certificates of Analysis (CoA) that detail purity verification methods, such as HPLC.
  • Manufacturer Reputation and Reliability: Partnering with an established manufacturer in China or other reputable regions is crucial. Look for suppliers with a proven track record in pharmaceutical intermediate production, adherence to GMP (Good Manufacturing Practice) standards where applicable, and robust quality control systems.
  • Supply Chain Stability: A stable and uninterrupted supply is vital. Inquire about the supplier's production capacity, inventory management, and logistics capabilities. Understanding their ability to meet large-volume orders and handle timely deliveries is essential.
  • Technical Support and Documentation: Reputable suppliers offer comprehensive technical support, including detailed product specifications, safety data sheets (SDS), and regulatory documentation such as DMF (Drug Master File) open parts if required. This support is invaluable for R&D scientists and regulatory affairs teams.
  • Pricing and Value: While quality is paramount, competitive pricing is also a significant consideration, especially for large-scale manufacturing. Obtaining multiple quotes from different suppliers can help you secure the best value. However, never compromise on quality for cost savings.

Navigating the Procurement Process

To effectively procure Sacubitril intermediate, consider the following steps:

  1. Identify Potential Suppliers: Utilize online B2B platforms, industry directories, and trade shows to identify potential manufacturers and suppliers. Search for terms like “Sacubitril supplier China,” “buy CAS 149709-62-6,” or “pharmaceutical intermediate manufacturer.”
  2. Request Quotes and Samples: Once you have shortlisted suppliers, request detailed quotes and product samples. Evaluate the samples for purity, appearance, and any other critical parameters specified in your requirements.
  3. Verify Credentials: Thoroughly vet the supplier's credentials, including their manufacturing facilities, quality certifications, and customer testimonials. Ensure they are a legitimate and capable supplier.
  4. Negotiate Terms: Discuss pricing, payment terms, delivery schedules, and any specific contractual requirements. A clear understanding of these terms will prevent future disputes.
  5. Place Orders and Monitor: Place your order and maintain open communication with the supplier throughout the production and shipping process.

Choosing the right manufacturer for your Sacubitril intermediate is a strategic decision that impacts your entire product lifecycle. By focusing on purity, reliability, and comprehensive support, you can secure a valuable partner for your pharmaceutical endeavors.