The pharmaceutical industry's constant drive for new and improved therapies necessitates a robust supply chain for critical raw materials and intermediates. Among these, Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate (CAS 256504-39-9) stands out as a high-value chemical. Its significance is deeply rooted in its role as a precursor for Riociguat, a vital drug for managing pulmonary hypertension. For pharmaceutical companies, understanding how to effectively procure this intermediate is paramount for operational success and product availability.

Why is this Intermediate Crucial?

Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate, with its specific molecular structure (C13H14FN3O2), provides the foundational elements for constructing the Riociguat molecule. The presence of the fluorobenzyl moiety and the pyrazole core makes it an ideal starting point for the complex synthetic routes employed in Riociguat production. Its typical purity of ≥98.0% ensures that downstream synthesis steps proceed smoothly, minimizing by-product formation and maximizing yield and drug efficacy. Manufacturers globally rely on this intermediate to maintain their production lines.

Navigating the Supply Landscape

When sourcing CAS 256504-39-9, pharmaceutical procurement managers often look towards established chemical manufacturing hubs. China has emerged as a dominant supplier for many pharmaceutical intermediates, including this one. Key considerations for sourcing include:

  • Manufacturer Reputation: Prioritizing manufacturers with a proven track record in producing high-purity intermediates for the pharmaceutical sector.
  • Quality Assurance: Thoroughly reviewing Certificates of Analysis (CoA) to confirm purity, chemical identity, and compliance with specifications.
  • Supply Stability: Assessing the supplier's production capacity and logistical capabilities to ensure consistent delivery schedules.
  • Price Negotiation: Engaging with multiple suppliers to obtain competitive pricing, especially for bulk purchases.

Many international buyers prefer to purchase from manufacturers who can provide comprehensive technical support and adhere to strict quality control measures. The ability to request samples for preliminary testing is also a crucial step in the vendor selection process.

The Value Proposition for Buyers

By securing a reliable supply of Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate, pharmaceutical manufacturers can ensure the continuous production of Riociguat, thereby meeting patient needs. The competitive pricing often available from Chinese manufacturers can also contribute to cost efficiencies. For those seeking to buy this intermediate, engaging with specialized chemical suppliers or manufacturers directly can streamline the procurement process. Obtaining a quote for bulk quantities is often the first step towards establishing a long-term supply agreement.

In conclusion, understanding the critical role of Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate as a Riociguat intermediate and mastering the art of sourcing it effectively from reliable manufacturers are essential for success in the pharmaceutical industry. Explore your options today to secure this vital chemical building block.