The efficacy of modern cardiac medications often hinges on the quality and availability of their constituent intermediates. Propafenone Hydrochloride (CAS 34183-22-7) is a critical pharmaceutical intermediate, vital for the synthesis of the potent anti-arrhythmic drug, Propafenone. This article examines the synthesis, quality specifications, and global supply landscape of Propafenone HCl, offering valuable information for R&D scientists and procurement specialists.

Chemical Profile and Synthesis of Propafenone Hydrochloride

Propafenone Hydrochloride, with the chemical name 1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (1:1), is characterized by its molecular formula C21H28ClNO3 and a molecular weight of 377.91. It typically appears as a white solid, with high purity (often 99%) being a standard requirement for pharmaceutical applications. While the specific synthesis routes are proprietary to manufacturers, they generally involve multi-step organic synthesis procedures designed to yield a highly pure final product suitable for API manufacturing.

The primary application of Propafenone HCl is as a direct precursor to Propafenone, a drug used to control serious heart rhythm disorders. Its role in the synthesis chain means that the quality of the intermediate directly impacts the safety and efficacy of the final pharmaceutical product. Therefore, sourcing from a reputable Propafenone HCl manufacturer is paramount.

Global Sourcing and Quality Assurance for Propafenone HCl

When seeking to buy Propafenone HCl, especially from China, it is crucial to work with suppliers who adhere to international quality standards. Key considerations include:

  • Purity Verification: Always demand a detailed Certificate of Analysis (CoA) confirming the 99% purity and other critical physical and chemical properties.
  • Supplier Reputation: Partner with experienced Propafenone HCl suppliers who have a track record of quality and reliability in the pharmaceutical chemical sector.
  • Packaging and Delivery: Ensure appropriate packaging (e.g., 25kg drums) and reliable global shipping options are available for your purchase.
  • Competitive Pricing: Compare quotes from various sources to secure the best Propafenone HCl price, particularly for wholesale quantities.

NINGBO INNO PHARMCHEM CO.,LTD. is a leading global manufacturer and supplier of pharmaceutical intermediates, including high-purity Propafenone Hydrochloride (CAS 34183-22-7). We are dedicated to providing consistent quality, exceptional service, and competitive wholesale pricing. To discuss your requirements or to obtain a quote for purchasing Propafenone HCl, please reach out to our expert team.