For organic chemists and synthetic researchers, a thorough understanding of the properties of chemical building blocks is fundamental to successful synthesis. 2-Fluoro-4-iodo-5-picoline (CAS 153034-94-7) is a pyridine derivative that offers a unique combination of reactivity and structural features, making it a valuable intermediate. This article outlines its key physical and chemical properties, relevant for researchers and procurement specialists seeking to utilize it effectively.

Key Physical Properties

When working with 2-Fluoro-4-iodo-5-picoline, understanding its physical characteristics is essential for handling, storage, and reaction planning:

  • Appearance: Typically described as an 'Off-white Solid' or 'White to off-white crystalline powder'. This visual characteristic is the first indicator of product quality.
  • Melting Point: Reported in the range of 40-45°C. This narrow melting point range suggests good purity and is useful for identification and quality checks.
  • Boiling Point: Approximately 244.3°C at 760mmHg. This higher boiling point indicates moderate volatility, important for distillation or purification processes.
  • Density: Around 1.892 g/cm³. This information can be useful in volumetric calculations.
  • Refractive Index: Reported as 1.587, a property used in quality control.

Crucial Chemical Properties and Reactivity

The chemical properties of 2-Fluoro-4-iodo-5-picoline dictate its utility in synthesis:

  • Molecular Formula and Weight: C6H5FIN, with a molecular weight of 237.01300. This precise information is fundamental for stoichiometric calculations in reactions.
  • Functional Groups: The presence of a pyridine ring, a fluorine substituent, and an iodine substituent are key. The iodine atom is particularly important as a leaving group, facilitating a wide array of cross-coupling reactions (e.g., Suzuki, Sonogashira, Stille, Heck).
  • Stability: The compound is generally stable under normal temperatures and pressures, making it relatively easy to handle and store. However, it's always prudent to store it according to recommended conditions, such as in a cool, dry, well-ventilated area, away from incompatible substances.
  • Solubility: While specific solubility data can vary, it is often soluble in common organic solvents like methanol, contributing to its ease of use in reactions.

Procurement for Research and Production

For scientists and procurement managers, sourcing this chemical requires attention to detail. When looking to buy 2-Fluoro-4-iodo-5-picoline, it's crucial to partner with a trusted manufacturer or supplier that can provide accurate property data and verify product quality. Always request a Certificate of Analysis (CoA) that confirms the purity and relevant physical properties. Understanding the competitive price and lead times from suppliers in China can significantly aid in project planning and budget management.

The detailed understanding of 2-Fluoro-4-iodo-5-picoline's properties empowers chemists to design more efficient synthetic routes and develop novel compounds for pharmaceutical, agrochemical, and material science applications. By ensuring access to high-quality material from reliable sources, researchers can confidently advance their innovative projects.