In the realm of pharmaceutical chemistry, understanding the detailed properties of key intermediates is fundamental for successful synthesis and product development. (2R)-2-Methylbut-3-enoic Acid, identified by its CAS number 20626-49-7, is one such compound that plays a significant role, particularly as an intermediate for Milvexian. This article explores its essential chemical and physical characteristics, providing valuable insights for R&D scientists and procurement managers looking to buy this critical substance.

Chemical Identity and Structure

(2R)-2-Methylbut-3-enoic Acid has the molecular formula C5H8O2 and a molecular weight of approximately 100.12 g/mol. Its structure features a carboxylic acid group and a terminal alkene, with a chiral center at the second carbon atom, specifically in the (R) configuration. This specific stereochemistry is often critical for its biological activity or its role in subsequent stereoselective synthesis steps. Common synonyms include (2R)-2-Methyl-3-butenoic acid and R-2-Methyl-3-butenoic acid.

Key Physical and Chemical Properties

When you buy (2R)-2-Methylbut-3-enoic Acid, understanding its physical state and reactivity is crucial for handling and processing. Based on available data:

  • Appearance: Typically supplied as a white to off-white powder or solid.
  • Purity: High purity, often exceeding 96% or 98%, is standard for pharmaceutical applications. Buyers should always verify the purity specifications from their supplier.
  • Density: Reported around 1.0±0.1 g/cm³.
  • Boiling Point: Approximately 176.7±9.0 °C at standard atmospheric pressure.
  • Flash Point: Around 74.3±13.9 °C, indicating moderate flammability and the need for appropriate handling procedures.
  • Vapor Pressure: Low, estimated at 0.5±0.7 mmHg at 25°C, suggesting low volatility at room temperature.
  • Index of Refraction: Approximately 1.436.
  • LogP Value: Around 0.89, indicating moderate hydrophobicity and solubility in both polar and nonpolar solvents, facilitating its use in various reaction media.
  • Chirality: The (R) configuration is a defining characteristic, essential for applications requiring stereospecificity.

Handling and Storage Considerations

Given its properties, (2R)-2-Methylbut-3-enoic Acid should be stored in a cool, dry, and well-ventilated area, away from ignition sources. Storage at refrigerated temperatures (e.g., 0-8 °C) might be recommended by some suppliers to maintain stability over longer periods. Safety data sheets (SDS/MSDS) should be consulted for detailed handling instructions, including personal protective equipment (PPE) recommendations such as gloves, safety glasses, and respiratory protection, especially when dealing with powders or fine dust.

Importance for R&D and Manufacturing

For R&D scientists, understanding these properties helps in designing synthetic routes, optimizing reaction conditions, and predicting solubility and reactivity. Procurement managers can use this information to assess storage needs, safety protocols, and the suitability of the compound for their manufacturing processes. When you plan to buy (2R)-2-Methylbut-3-enoic Acid, always request a Certificate of Analysis (CoA) from the supplier to confirm that the product meets your required specifications.

Conclusion

(2R)-2-Methylbut-3-enoic Acid (CAS 20626-49-7) is a valuable chiral intermediate with a well-defined set of chemical and physical properties. A thorough understanding of these characteristics is essential for its effective use in pharmaceutical research and development, as well as for efficient manufacturing processes. If your organization requires this compound, engaging with a reliable supplier who can provide comprehensive product data is key to successful procurement.