For chemists and formulators involved in pharmaceutical synthesis, a deep understanding of the properties of key intermediates is fundamental to successful product development. 4,6-Dichloro-1H-pyrrolo[2,3-b]pyridine (CAS 5912-18-5), a critical heterocyclic building block, possesses a unique set of chemical and physical attributes that dictate its utility and handling in synthetic processes.

This compound, often referred to by its synonym 4,6-dichloro-7-azaindole, presents as a light yellow to brown solid, with a melting point typically ranging from 207-208°C. Its molecular formula is C7H4Cl2N2, and its molecular weight is approximately 187.03 g/mol. The presence of two chlorine atoms on the pyrrolo[2,3-b]pyridine core significantly influences its electronic properties and reactivity. These chlorine substituents activate the heterocyclic system towards nucleophilic aromatic substitution reactions, making it a versatile substrate for introducing diverse functionalities. This reactivity is precisely what makes it an indispensable intermediate for manufacturers of advanced pharmaceutical ingredients.

In terms of chemical reactions, 4,6-Dichloro-1H-pyrrolo[2,3-b]pyridine can undergo various transformations. Beyond nucleophilic substitution, its aromatic nature allows for electrophilic aromatic substitution, albeit under more forcing conditions due to the electron-deficient pyridine ring. The NH proton in the pyrrole ring is also amenable to deprotonation and subsequent reactions. Its stability is generally good under recommended storage conditions, typically in an inert atmosphere at 2-8°C, which is crucial for maintaining its integrity as a raw material. When considering purchasing this compound, understanding these properties helps in optimizing reaction conditions and ensuring the desired outcomes in your synthesis projects.

The compound's solubility characteristics are also important. While specific solubility data might vary, such heterocyclic aromatic compounds are generally less soluble in polar protic solvents like water and more soluble in polar aprotic organic solvents. This information is vital for solvent selection in reaction and purification steps. For researchers and businesses seeking to buy 4,6-Dichloro-1H-pyrrolo[2,3-b]pyridine, partnering with a reliable supplier like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to high-quality material with detailed technical specifications, facilitating smoother integration into your synthetic workflows.