In the vast landscape of organic chemistry, certain compounds emerge as pivotal building blocks, enabling a myriad of downstream applications. 6-Methylnicotinic Acid, also known by its CAS number 3222-47-7, is one such compound, distinguished by its unique chemical structure and its critical role as an intermediate in various industrial sectors. This article explores its fundamental properties and highlights its significance in modern chemical manufacturing.

Chemical Identity and Physical Characteristics

6-Methylnicotinic Acid possesses the molecular formula C7H7NO2 and a molecular weight of approximately 137.14 g/mol. Its structure features a pyridine ring substituted with a methyl group at the 6-position and a carboxylic acid group at the 3-position. This combination of functional groups dictates its chemical behavior and reactivity.

Physically, 6-Methylnicotinic Acid typically appears as a white powder or crystalline solid. Its appearance is a crucial indicator of purity for many applications. The material is generally stable under recommended storage conditions, which include keeping it in a dark, cool, ventilated, and dry environment. This stability is vital for manufacturers and end-users alike, ensuring product integrity over time. Its melting point, typically in the range of 209-213°C, further characterizes its solid state at room temperature.

Industrial Significance and Applications

The industrial importance of 6-Methylnicotinic Acid is multifaceted:

  • Pharmaceutical Intermediate: Its most prominent role is as a key intermediate in the synthesis of pharmaceuticals. It is essential for producing Etoricoxib, a selective cyclooxygenase-2 (COX-2) inhibitor used to treat inflammatory conditions like arthritis and osteoarthritis. The demand for high-purity 6-Methylnicotinic Acid (often specified at ≥99%) is directly linked to the production volumes of such critical medications. Pharmaceutical companies seeking to buy this intermediate rely on manufacturers that can guarantee consistent quality and supply chain security.
  • Organic Synthesis: Beyond pharmaceuticals, 6-Methylnicotinic Acid serves as a versatile building block in general organic synthesis. Its reactive sites allow chemists to perform various transformations, leading to the creation of novel compounds for research and industrial applications. This makes it valuable for R&D laboratories and fine chemical manufacturers.
  • Agrochemical Research: Emerging applications also suggest its utility in the development of novel agrochemicals, contributing to advancements in crop protection and yield enhancement.

Sourcing and Manufacturing Considerations

For businesses looking to procure 6-Methylnicotinic Acid, understanding the market dynamics is crucial. The 6-methylnicotinic acid price is influenced by factors such as raw material costs, production scale, and global demand. Working with established manufacturers and suppliers, particularly those in regions with strong chemical production capabilities like China, can offer advantages in terms of cost-effectiveness and supply chain reliability. Companies such as NINGBO INNO PHARMCHEM CO.,LTD. specialize in providing high-quality intermediates like 6-Methylnicotinic Acid, ensuring that industrial partners can meet their production and research objectives.

In summary, 6-Methylnicotinic Acid is a compound of significant industrial value, primarily due to its role as a pharmaceutical intermediate and its broad utility in organic synthesis. Its well-defined physical and chemical properties, coupled with reliable sourcing from reputable manufacturers, underscore its continuing importance in the chemical industry.