Ethyl (R)-3-hydroxybutanoate, identified by its CAS number 24915-95-5, is a crucial organic compound with significant applications, particularly within the pharmaceutical and fine chemical industries. As a chiral building block, its precise stereochemistry is key to its utility. This article explores its fundamental properties, common applications, and the synthetic approaches used to produce it, offering insights for researchers and procurement specialists.

Chemically, Ethyl (R)-3-hydroxybutanoate is an ester featuring a hydroxyl group at the beta-carbon position. It is typically presented as a clear, colorless liquid with a molecular weight of approximately 132.16 g/mol. Key physical properties include a boiling point of 75-76 °C at 12 mmHg and a density of around 1.017 g/mL at 25 °C. Crucially, it exhibits specific optical activity, with an alpha value often cited around -45.5 º (589nm, c=1, CHCl3) or [α]20/D 46°, indicating its (R)-configuration. This optical purity is vital for its downstream applications, particularly in stereoselective synthesis.

The primary application of Ethyl (R)-3-hydroxybutanoate is as a chiral synthon in organic chemistry. It is widely used in the pharmaceutical industry for the synthesis of various biologically active compounds and Active Pharmaceutical Ingredients (APIs). Its structure allows for easy modification and incorporation into larger, complex molecules, making it a preferred intermediate for creating enantiomerically pure drugs. Beyond pharmaceuticals, it also finds use in the synthesis of specialty chemicals and in academic research for exploring new reaction pathways and molecular structures.

The synthesis of Ethyl (R)-3-hydroxybutanoate often involves stereoselective methods to ensure the desired (R)-enantiomer is produced with high purity. One common route involves the stereoselective hydrogenation of diethyl succinate or the reduction of ethyl acetoacetate using chiral catalysts. Another method can involve the enzymatic resolution of racemic mixtures or the direct synthesis from precursors like (R)-β-Butyrolactone. For those looking to buy Ethyl (R)-3-hydroxybutanoate, understanding these synthetic routes can provide valuable insight into the quality and pricing offered by different manufacturers.

When sourcing this chemical, it is important to partner with suppliers who can provide consistent quality and reliable pricing. Many organizations turn to manufacturers in China, like NINGBO INNO PHARMCHEM CO.,LTD., who offer competitive pricing and a steady supply of high-purity chemical intermediates. Access to detailed product specifications, MSDS sheets, and responsive customer support are critical factors when making a purchase decision. Ensuring you buy from a reputable supplier guarantees the integrity of your research and production processes.

In summary, Ethyl (R)-3-hydroxybutanoate is a high-value chiral intermediate with significant applications in the synthesis of pharmaceuticals and fine chemicals. Its specific properties, particularly its optical activity, make it an indispensable tool for chemists engaged in asymmetric synthesis. Reliable sourcing from quality manufacturers is key to leveraging its full potential in scientific and industrial applications.