2-Chloronicotinyl Chloride, identified by its CAS number 49609-84-9, is a significant chemical intermediate with a distinct set of properties that make it highly valuable across multiple industries. As an off-white to brown solid, it presents with a molecular formula of C6H3Cl2NO and a molecular weight of approximately 176.00 g/mol. Its melting point typically falls in the range of 38-44 °C, classifying it as a low-melting solid, and it boasts a boiling point of around 120 °C at 10 mmHg. Understanding these physical characteristics is crucial for its handling, storage, and application in synthesis.

Chemically, 2-Chloronicotinyl Chloride is a reactive acyl chloride. Its structure features a pyridine ring substituted with a chlorine atom and an acid chloride group. This combination of functionalities imparts significant reactivity, making it a sought-after intermediate for acylation reactions. It is sensitive to moisture, a common trait for acyl chlorides, necessitating careful storage in dry conditions to maintain its integrity and reactivity. Its solubility in solvents like chloroform, DMSO, and ethyl acetate further enhances its utility in various reaction media.

The applications of 2-Chloronicotinyl Chloride are diverse, spanning critical sectors such as pharmaceuticals and agrochemicals. In the pharmaceutical industry, it serves as a vital building block for synthesizing active pharmaceutical ingredients (APIs), including potential anti-inflammatory and anti-cancer agents. Its role in creating these complex molecules underscores its importance in drug discovery and development. For agrochemical manufacturers, this intermediate is used to enhance the efficacy of pesticides and herbicides, contributing to more effective crop protection strategies.

For businesses looking to procure this compound, identifying a reliable manufacturer and supplier is paramount. Factors such as consistent purity (often specified as ≥98% by titration), competitive pricing, and robust supply chain management are key considerations. When you need to buy 2-Chloronicotinyl Chloride, engaging with experienced chemical providers ensures you receive a product that meets your stringent requirements and supports your product development goals.