For chemists and researchers working in advanced synthesis, understanding the characteristics of key chemical intermediates is crucial. 2-Fluoro-5-methylpyridine (CAS 2369-19-9) is one such compound, recognized for its utility as a building block in various chemical sectors, particularly pharmaceuticals and agrochemicals. This article provides an in-depth look at its properties and applications, guiding potential buyers on sourcing this vital intermediate.

Key Chemical and Physical Properties

2-Fluoro-5-methylpyridine presents itself as a colorless liquid. Its molecular formula is C6H6FN, with a molecular weight of approximately 111.12. Key physical properties reported include a density of 1.072 g/mL at 25 °C and a boiling point of 158-159 °C. The presence of a fluorine atom on the pyridine ring significantly influences its reactivity, making it amenable to various synthetic transformations. Its flash point is noted at 119 °F, indicating its flammable nature and the need for appropriate handling precautions.

Diverse Applications Across Industries

The primary application for 2-Fluoro-5-methylpyridine lies in its role as a pharmaceutical intermediate. It serves as a critical component in the synthesis of numerous active pharmaceutical ingredients (APIs), particularly those designed to treat neurological disorders, where its fluorine substituent can enhance drug efficacy and pharmacokinetic profiles. Beyond pharmaceuticals, it finds use in the agrochemical industry for developing effective crop protection agents and in material science for creating advanced polymers and coatings with improved thermal and chemical resistance.

Sourcing 2-Fluoro-5-methylpyridine: What Buyers Need to Know

When looking to purchase 2-Fluoro-5-methylpyridine, it is essential to source from reliable manufacturers and suppliers. For businesses in R&D or production, securing a consistent supply of high-purity material (≥99.0%) is paramount. Many reputable chemical suppliers, including those based in China, offer this intermediate. When requesting a quotation, buyers should specify their required quantity, purity level, and packaging needs. Comparing pricing and verifying the supplier's quality control certifications are critical steps in the procurement process to ensure you buy a dependable product.

  • Pharmaceutical Synthesis: A key intermediate for API development.
  • Agrochemicals: Used in the formulation of pesticides and herbicides.
  • Material Science: Contributes to advanced materials with enhanced properties.
  • Organic Synthesis: A versatile building block for complex molecular structures.

By understanding the properties and application landscape of 2-Fluoro-5-methylpyridine, R&D professionals and procurement managers can make informed decisions when seeking to buy this vital chemical intermediate, ensuring success in their respective fields.