Understanding the detailed properties of chemical intermediates is crucial for their successful application in complex syntheses. 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one, with its CAS number 536760-29-9, is a prime example of a compound whose specific characteristics make it invaluable in the pharmaceutical industry, most notably as an intermediate for the anticoagulant drug Apixaban.

This dihydropyridinone derivative typically presents as a white powder, indicating a relatively pure crystalline form. Its molecular formula, C11H9ClN2O3, and molecular weight of approximately 252.65 g/mol, provide fundamental parameters for chemical calculations and process design. The compound's structure features a chloro substituent at the 3-position and a 4-nitrophenyl group attached to the nitrogen atom within the dihydropyridinone ring. These features contribute to its reactivity and solubility profiles, which are generally moderate in polar organic solvents while being limited in aqueous environments.

From a stability perspective, 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one exhibits moderate thermal stability, making it suitable for standard storage conditions, typically between 2-8°C. Its handling requires adherence to standard chemical safety protocols, as indicated by its GHS hazard statements which may include warnings about potential long-lasting effects on aquatic life. At NINGBO INNO PHARMCHEM CO.,LTD., we ensure that our product is stored and packaged appropriately to maintain its integrity and purity.

The primary application driving the demand for this compound is its role as a key intermediate in the synthesis of Apixaban. The precise arrangement of functional groups within 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one is essential for building the complex molecular architecture of Apixaban. Beyond this critical role, its utility extends to general organic synthesis and research, where it can serve as a versatile building block for creating novel heterocyclic compounds with potential pharmacological activities.

Our expertise at NINGBO INNO PHARMCHEM CO.,LTD. lies not only in producing this intermediate to high purity standards but also in optimizing its synthesis pathways. We continuously explore advanced techniques, including green chemistry approaches, to ensure sustainable and cost-effective production. Whether you are involved in Apixaban intermediate manufacturing or broader pharmaceutical R&D, understanding the properties of this compound is key to successful outcomes.