3-Chloro-4-fluoroaniline, identified by its CAS number 367-21-5, is a chemical compound of significant interest in various scientific and industrial sectors, most notably in pharmaceutical synthesis. Understanding its intrinsic properties is key for researchers and procurement specialists aiming to leverage its potential effectively. This article delves into the physical and chemical characteristics of this compound, alongside its primary applications, providing valuable insights for those looking to buy or utilize it.

Physical and Chemical Profile of 3-Chloro-4-fluoroaniline

As outlined in technical specifications, 3-Chloro-4-fluoroaniline typically presents as a white crystalline powder. This solid form is convenient for handling, storage, and precise measurement in chemical reactions. Its molecular formula, C6H5ClFN, translates to a molecular weight of approximately 145.56 g/mol. Further characterization reveals a density of around 1.226 g/cm³ and a melting point in the range of 42-44°C. The boiling point is noted at 227-228°C, and a flash point exceeding 230°F indicates a relatively stable compound under normal conditions. Its refractive index is typically measured between 1.54 and 1.542.

The stability of 3-Chloro-4-fluoroaniline is a noteworthy feature for industrial applications. It is generally stable but should be kept away from incompatible substances such as strong oxidizing agents, acids, acid chlorides, and acid anhydrides. Awareness of these incompatibilities is vital for safe storage and handling by chemical formulators and production teams.

Key Applications: Beyond the Lab Bench

The primary significance of 3-Chloro-4-fluoroaniline lies in its role as a versatile organic building block. Its most prominent application is as a critical intermediate in the synthesis of Gefitinib, a well-known pharmaceutical agent used in targeted cancer therapy. This specific application highlights the compound's importance in the pharmaceutical industry, driving demand from drug manufacturers worldwide.

Beyond Gefitinib, its unique halogenated aniline structure makes it a valuable starting material for the creation of other biologically active compounds. Organic chemists and product development teams might utilize it to synthesize novel molecules with potential applications in medicinal chemistry, agrochemicals, or material science. For those involved in advanced organic synthesis, procuring this chemical from a reliable supplier is the first step in innovation.

Sourcing High-Quality 3-Chloro-4-fluoroaniline

When sourcing 3-Chloro-4-fluoroaniline, ensuring the required purity (≥99.0%) and low moisture content (≤0.2%) is paramount for successful downstream applications. Buyers seeking to purchase this intermediate will find numerous suppliers, particularly in China, known for their manufacturing capabilities. For businesses looking to establish a consistent supply chain and obtain competitive pricing, engaging with established manufacturers is a prudent strategy. Whether for research quantities or large-scale production, understanding the supplier's quality assurance and logistical capabilities is essential. If you're seeking a manufacturer for this vital chemical, consider exploring options that emphasize quality control and timely delivery.

In summary, 3-Chloro-4-fluoroaniline is a compound with well-defined properties that make it indispensable in pharmaceutical synthesis and other areas of organic chemistry. Its role as a Gefitinib intermediate underscores its commercial importance. For researchers and manufacturers, securing a high-quality supply is crucial for their ongoing projects and production needs.