For chemists engaged in organic synthesis, understanding the fundamental properties of chemical intermediates is crucial for successful reaction design and product development. 3-Methylquinoline (CAS 612-58-8) is a prime example of such a versatile intermediate, offering a unique combination of aromaticity and reactivity valuable across multiple scientific disciplines.

Chemical Profile of 3-Methylquinoline

3-Methylquinoline, with the molecular formula C10H9N and a molecular weight of 143.19 g/mol, is a heterocyclic aromatic compound. Its key physical and chemical properties include:

  • Appearance: Typically a light yellow liquid.
  • Melting Point: 16-17 °C, indicating it can exist as a solid or liquid near room temperature.
  • Boiling Point: Approximately 252-253 °C, signifying its relatively low volatility.
  • Density: Around 1.069 g/mL at 25 °C.
  • Refractive Index: n20/D 1.615.
  • Purity: Commonly available with purity levels of 95% or higher, essential for precise chemical reactions.
  • Acidity Factor (pKa): Predicted at 5.17 ± 0.11.

These properties make 3-Methylquinoline suitable for a wide range of chemical transformations, including electrophilic aromatic substitution, nucleophilic addition, and as a ligand in coordination chemistry.

Applications in Chemical Synthesis

The utility of 3-Methylquinoline extends across several industrial and research sectors:

  • Pharmaceutical Intermediates: It serves as a fundamental building block for synthesizing active pharmaceutical ingredients (APIs) and their precursors. Its quinoline core is prevalent in many therapeutic agents.
  • Agrochemicals: It can be used in the development of crop protection chemicals and herbicides.
  • Dyes and Pigments: As discussed previously, it’s a key intermediate in creating various colorants.
  • Research and Development: Its versatile reactivity makes it a valuable reagent for academic and industrial R&D labs exploring new synthetic methodologies and molecular structures.

Sourcing 3-Methylquinoline from Reliable Manufacturers

When planning your next synthesis project requiring 3-Methylquinoline, it is vital to buy from a reputable manufacturer or supplier. Look for companies that can provide the specified purity (e.g., 95%+), offer competitive pricing for bulk purchases, and supply essential documentation like Certificates of Analysis. China-based manufacturers are often excellent sources for this chemical, ensuring both quality and cost-effectiveness. Request a quote for CAS 612-58-8 to integrate this essential intermediate into your laboratory or production workflow.