For R&D scientists and procurement managers in the chemical and pharmaceutical sectors, a deep understanding of key chemical intermediates is essential for successful project development and efficient supply chain management. 4-[[(4-Fluorophenyl)imino]methyl]-phenol, identified by CAS number 3382-63-6, is one such compound. This article provides a comprehensive overview of its properties, synthesis pathways, and varied applications, making it easier for professionals to source and utilize this valuable chemical.

Chemically, 4-[[(4-Fluorophenyl)imino]methyl]-phenol is characterized by its off-white to dark yellow solid appearance and a melting point typically ranging between 179.0 to 183.0 °C. Its molecular formula is C13H10FNO, with a molecular weight of 215.22 g/mol. The molecule features a phenol group and a fluorophenyl group linked by an imine bond, a structure that imparts specific reactivity and utility. This structure makes it an excellent candidate for further chemical modifications.

The primary synthesis route for this compound involves a Schiff base formation through the condensation reaction of 4-hydroxybenzaldehyde and 4-fluoroaniline. This reaction is commonly carried out in alcoholic solvents such as ethanol or methanol, often under reflux conditions. The yield can be optimized to achieve high purity, often exceeding 95%, which is critical for its application as a pharmaceutical intermediate. For manufacturers looking to buy 4-[[(4-Fluorophenyl)imino]methyl]-phenol, understanding these synthesis parameters helps in evaluating the quality offered by different suppliers.

Beyond its significant role as an intermediate in the synthesis of Ezetimibe, 4-[[(4-Fluorophenyl)imino]methyl]-phenol also finds applications in coordination chemistry. It can act as a ligand, forming complexes with various metal ions. These metal complexes may exhibit catalytic activity or possess unique material properties, opening doors for research in areas like catalysis and materials science. Additionally, its properties make it useful in analytical chemistry as a reagent for specific detection methods.

For procurement professionals, sourcing this intermediate requires careful consideration of suppliers, purity grades, and pricing. Partnering with reliable manufacturers in China can ensure a steady supply at competitive prices. It is always advisable to request detailed product specifications and CoAs to confirm suitability for your intended application, whether it's for large-scale pharmaceutical production or specialized R&D projects. Understanding the chemical profile and application landscape of 4-[[(4-Fluorophenyl)imino]methyl]-phenol empowers informed decision-making for any chemical procurement strategy.