In the realm of fine chemicals and pharmaceutical intermediates, understanding the detailed properties and applications of key compounds is essential for scientists and procurement specialists alike. 4'-Bromomethyl-2-cyanobiphenyl, identified by CAS number 114772-54-2, stands out as a compound of significant industrial importance, primarily due to its role in synthesizing Sartan-class antihypertensive drugs.

Chemically, 4'-Bromomethyl-2-cyanobiphenyl is an organic compound with the molecular formula C14H10BrN. It presents as an off-white to cream-colored crystalline powder. Its physical and chemical properties are well-documented, including a melting point typically in the range of 125-128°C, a boiling point around 413.2°C, and a density of approximately 1.43 g/cm³. The compound is generally insoluble in water but shows some solubility in organic solvents like acetonitrile and chloroform. The presence of the bromomethyl group (-CH2Br) makes it a reactive intermediate, susceptible to nucleophilic substitution reactions, a characteristic that is exploited in its synthetic applications.

The synthesis of 4'-Bromomethyl-2-cyanobiphenyl commonly involves the bromination of its precursor, 2-cyano-4-methylbiphenyl. Advanced synthetic routes often employ reagents like dibromohydantoin under controlled conditions, employing methods such as continuous flow chemistry with LED light irradiation to optimize yield and purity. The efficiency of these synthesis processes is critical for manufacturers aiming to produce this intermediate economically and at scale, often achieving yields upwards of 90% with high purity.

The principal application of 4'-Bromomethyl-2-cyanobiphenyl is its function as a crucial intermediate in the production of various Sartan APIs. These include widely used medications such as Losartan, Valsartan, Irbesartan, and Telmisartan, which are vital in managing cardiovascular diseases. In these syntheses, the reactive bromomethyl group of 4'-Bromomethyl-2-cyanobiphenyl is typically reacted with an appropriate amine or tetrazole moiety to build the characteristic structure of the Sartan molecule.

Beyond its primary use in Sartan synthesis, this versatile intermediate can also be employed in the preparation of other heterocyclic compounds and derivatives, making it valuable for broader organic synthesis research and development. The chemical industry relies on such well-defined intermediates to explore new molecular entities and optimize existing synthetic pathways.

For pharmaceutical companies and research institutions, sourcing high-purity 4'-Bromomethyl-2-cyanobiphenyl is essential. Manufacturers committed to quality assurance provide detailed specifications and analytical data to confirm purity levels (often ≥99.0%) and identify any residual impurities. When considering purchasing this compound, it is advisable to engage with established chemical suppliers and manufacturers who can offer consistent quality, competitive pricing, and reliable delivery, ensuring your R&D or production processes are supported effectively.