For chemists and researchers in the fine chemical and pharmaceutical sectors, a deep understanding of compound properties is crucial for successful application. 5-Bromo-2-chloropyrimidine, identified by CAS number 32779-36-5, is a heterocyclic organic compound that offers a unique combination of reactivity and structural features, making it highly sought after for various synthetic purposes.

The typical appearance of 5-Bromo-2-chloropyrimidine is an off-white to beige crystalline powder. Its physical characteristics, such as a melting point in the range of 73-79 °C (lit.), provide important parameters for handling and processing. Solubility data indicates it is insoluble in water but slightly soluble in common organic solvents like methanol and DMSO, which is a common trait for such halogenated organic compounds.

The chemical properties of 5-Bromo-2-chloropyrimidine are what truly define its utility. As a dihalopyrimidine, it features a reactive bromine atom at the 5-position and a chlorine atom at the 2-position. This structural arrangement makes it an excellent electrophile. It is widely employed in cross-coupling reactions, including Suzuki-Miyaura, Stille, and Buchwald-Hartwig amination reactions, enabling the formation of new carbon-carbon and carbon-heteroatom bonds. These reactions are foundational in modern organic synthesis for constructing complex molecular architectures.

The primary application for 5-Bromo-2-chloropyrimidine is as a pharmaceutical intermediate. Its role in the synthesis of Macitentan, a drug for pulmonary hypertension, is well-documented. Beyond this specific application, it serves as a versatile building block in drug discovery programs for creating novel therapeutic agents. Researchers also utilize it in the synthesis of agrochemicals and other fine chemicals where a substituted pyrimidine scaffold is desired.

For those looking to buy 5-Bromo-2-chloropyrimidine, partnering with a reliable manufacturer and supplier from China offers distinct advantages. We provide this critical intermediate with guaranteed quality and competitive pricing, ensuring that your research and development projects have access to the necessary materials without compromising on cost or performance.

In summary, the well-defined properties and diverse reactivity of 5-Bromo-2-chloropyrimidine make it an indispensable tool for synthetic chemists. Whether for advanced pharmaceutical intermediates or general organic synthesis, understanding its characteristics and sourcing it from trusted suppliers is key to successful outcomes.