In the realm of synthetic chemistry and drug discovery, specialized amino acid derivatives are indispensable tools for creating molecules with tailored properties. Fmoc-L-3-(2-Thienyl)-alanine (CAS 130309-35-2) is one such compound, prized for its unique structure and versatile applications. This article explores its key chemical characteristics and the broad spectrum of its uses, emphasizing the importance of sourcing from qualified manufacturers and suppliers.

Fmoc-L-3-(2-Thienyl)-alanine is an unnatural amino acid characterized by the presence of a thiophene ring attached to its beta-carbon and the Fmoc (fluorenylmethoxycarbonyl) protecting group on the alpha-amino nitrogen. The Fmoc group provides excellent acid-labile and base-labile protection, making it ideal for solid-phase peptide synthesis (SPPS) where it can be selectively removed under mild basic conditions without damaging the growing peptide chain or other sensitive functional groups. The thiophene ring, a sulfur-containing heterocycle, introduces distinct electronic and steric properties, which can significantly influence the conformation, binding affinity, and pharmacokinetic profile of peptides into which it is incorporated. This makes it a sought-after building block for designing peptides with enhanced biological activity and stability, particularly in fields like medicinal chemistry.

When researchers need to buy Fmoc-L-3-(2-Thienyl)-alanine, they often look for specific purities, typically advertised as 97% or 99% by High-Performance Liquid Chromatography (HPLC). This level of purity is critical to ensure the success of complex synthesis protocols and to obtain reliable experimental results. A reputable Fmoc-L-3-(2-Thienyl)-alanine supplier will provide comprehensive documentation, including Certificates of Analysis (COA), which detail the product’s purity and other critical specifications. Sourcing from a trusted CAS 130309-35-2 manufacturer, especially from China, often provides access to high-quality materials at competitive price points.

The applications of Fmoc-L-3-(2-Thienyl)-alanine are diverse and impactful. Its primary use is in SPPS for constructing complex peptide sequences. These peptides can then be utilized in drug discovery programs, where the thiophene moiety can enhance drug potency or target specificity, for example, in oncology or neurological disorder treatments. Beyond direct therapeutic applications, it is also valuable in bioconjugation strategies, enabling the precise linkage of peptides to various molecular platforms for targeted delivery systems or diagnostic tools. Furthermore, it plays a role in protein engineering research, aiding in the study and modification of protein structures and functions.

For organizations requiring Fmoc-Thi-OH bulk order quantities, partnering with an experienced chemical manufacturer is key. Such suppliers typically offer flexible packaging options and can support large-scale production needs. A reliable manufacturer of Fmoc-L-3-(2-Thienyl)-alanine will have robust quality assurance systems in place to guarantee product consistency and supply chain stability. When you seek to purchase Fmoc-L-3-(2-Thienyl)-alanine, engaging with a well-vetted China supplier can streamline your procurement, offering a cost-effective and efficient solution for obtaining this essential chemical intermediate.

In summary, Fmoc-L-3-(2-Thienyl)-alanine is a powerful tool for synthetic chemists and pharmaceutical researchers. Understanding its chemical properties and diverse applications, coupled with diligent sourcing from reputable manufacturers, empowers innovation in peptide synthesis and drug development.