For chemists and lab technicians working with specialized organic compounds, a thorough understanding of product properties and safe handling procedures is paramount. 2'-Bromo-5'-fluoroacetophenone (CAS 1006-33-3) is one such compound, vital for various synthetic applications. This article explores its key characteristics, from physical appearance to safety guidelines, providing essential knowledge for anyone looking to buy 2'-Bromo-5'-fluoroacetophenone or work with it.

Physical and Chemical Profile

2'-Bromo-5'-fluoroacetophenone presents as a clear, pale lemon/lime liquid, offering an initial visual cue to its state. Its molecular formula is C8H6BrFO, and it has a molecular weight of 217.04. Key physical properties include a boiling point of 144℃ at 18 mmHg, indicating its volatility under reduced pressure. Crucially, it is soluble in methanol, which is a common and useful characteristic for many organic reactions and purification processes.

Key Properties Relevant to Synthesis

  • Appearance: Clear, pale lemon/lime liquid.
  • Molecular Formula: C8H6BrFO
  • Molecular Weight: 217.04 g/mol
  • Boiling Point: 144℃/18mm
  • Solubility: Soluble in methanol.
  • Purity: Typically available at 98% or higher.

These specifications are vital for researchers and formulators to ensure the compound's suitability for their intended synthetic pathways, whether for pharmaceutical intermediates or other fine chemical applications. When sourcing this material, always confirm the purity offered by your chosen supplier or manufacturer.

Safety and Handling Precautions

As with many organic intermediates, 2'-Bromo-5'-fluoroacetophenone requires careful handling. Safety data sheets (SDS) typically classify it as an irritant, with hazard statements including H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Therefore, appropriate personal protective equipment (PPE) is essential:

  • Skin Protection: Wear chemical-resistant gloves (e.g., nitrile or neoprene) and protective clothing to prevent skin contact.
  • Eye Protection: Safety goggles or a face shield should be worn to protect the eyes from splashes or vapors.
  • Respiratory Protection: If working in poorly ventilated areas or if there's a risk of aerosol formation, use appropriate respiratory protection, such as a respirator with an organic vapor cartridge.

Proper storage is also critical. It should be kept in a cool, dry, and well-ventilated place, with containers tightly closed to prevent moisture absorption and contamination. Avoiding contact with incompatible materials is also a key safety measure.

Where to Buy 2'-Bromo-5'-fluoroacetophenone

For those seeking to purchase 2'-Bromo-5'-fluoroacetophenone, it is advisable to engage with established chemical suppliers and manufacturers. Obtaining a quotation from a reputable manufacturer in China or a specialized chemical distributor ensures you receive material that meets quality standards and is handled with appropriate safety protocols. Always consult the SDS before use.