For any chemist or procurement specialist working with fine chemicals, understanding the properties and safe handling of each compound is paramount. 2-Methyl-4(5)-iodo-1H-imidazole (CAS 73746-45-9) is a key organic intermediate, and familiarity with its characteristics ensures its effective and safe utilization in synthesis and research. This article provides essential information for anyone looking to purchase or work with this compound.

Key Chemical and Physical Properties:

2-Methyl-4(5)-iodo-1H-imidazole is typically supplied as a solid, often described as off-white to light yellow in appearance. Its molecular formula is C4H5IN2, with a molecular weight of approximately 208.00 g/mol. The compound's melting point is reported to be around 133°C, confirming its solid state under standard laboratory conditions. While its boiling point is predicted to be around 358.2°C, it's more common to handle it as a solid rather than a vaporized substance.

The presence of the iodine atom makes it a reactive species, particularly in metal-catalyzed cross-coupling reactions. The imidazole ring itself is a stable aromatic system, but the iodine substituent is a good leaving group, facilitating nucleophilic substitution or participation in oxidative addition steps in catalytic cycles. Its pKa is approximately 12.30, indicating it is a weak base.

Safety and Handling Precautions:

Like many fine chemicals, 2-Methyl-4(5)-iodo-1H-imidazole requires careful handling. According to GHS classifications, it may be harmful if swallowed (H302), cause skin irritation (H315), cause serious eye irritation (H319), and may cause respiratory irritation (H335). Therefore, when working with this compound, it is essential to:

  • Wear appropriate personal protective equipment (PPE): This includes safety goggles, chemical-resistant gloves (e.g., nitrile), and a lab coat.
  • Handle in a well-ventilated area or fume hood: To avoid inhalation of dust or vapors, particularly if heated or powdered.
  • Avoid contact with skin and eyes: In case of contact, immediately rinse with plenty of water and seek medical attention.
  • Prevent dust formation: Handle the solid carefully to minimize airborne particles.

Storage Recommendations:

To maintain the integrity and reactivity of 2-Methyl-4(5)-iodo-1H-imidazole, proper storage is crucial. It is recommended to store the compound under an inert atmosphere, such as nitrogen or argon, and at refrigerated temperatures, typically between 2–8°C. This helps to prevent degradation due to moisture or oxidation.

Procurement Information:

For researchers and procurement managers looking to purchase 2-Methyl-4(5)-iodo-1H-imidazole (CAS 73746-45-9), it is important to partner with reliable manufacturers and suppliers. When sourcing this chemical, consider factors such as purity specifications, availability in desired quantities, and competitive pricing. Many suppliers offer this compound, with competitive prices often available from manufacturers based in China. Requesting a quote from a trusted 'chemical supplier' can provide clarity on pricing and availability for your specific needs.

Understanding the properties and safety guidelines for 2-Methyl-4(5)-iodo-1H-imidazole empowers chemists to use it effectively and safely, contributing to successful research and development outcomes. Always refer to the latest Safety Data Sheet (SDS) provided by your supplier for the most comprehensive information.