For professionals working with fine chemicals and intermediates, a thorough understanding of product properties and safe handling procedures is fundamental. 4-Bromo-5-fluoro-2-nitrotoluene (CAS: 224185-19-7) is one such compound frequently utilized in organic synthesis and pharmaceutical research. This article aims to provide essential information regarding its physical and chemical characteristics, along with crucial safety guidelines.

Key Physical and Chemical Properties

4-Bromo-5-fluoro-2-nitrotoluene is typically described as a pale yellow powder. Its solid form is consistent with a melting point range of 59-63°C, as reported by various chemical databases. This moderate melting point indicates it is stable at room temperature but can be easily melted for certain reactions or purification processes. The molecular formula, C7H5BrFNO2, and a molecular weight of approximately 234.02 g/mol provide essential data for stoichiometric calculations in synthetic procedures. Its density is noted to be around 1.696±0.06 g/cm³, which is characteristic of halogenated aromatic compounds.

In terms of chemical reactivity, the compound's structure dictates its behavior. The bromine atom can participate in various nucleophilic substitution and cross-coupling reactions. The fluorine atom can influence the electronic properties of the aromatic ring and potentially affect the regioselectivity of further reactions. The nitro group, being an electron-withdrawing group, deactivates the aromatic ring towards electrophilic substitution but can be a site for reduction to an amino group, a common transformation in building complex molecules.

Safety Information and Handling Precautions

As with many organic intermediates, 4-Bromo-5-fluoro-2-nitrotoluene requires careful handling. Safety Data Sheets (SDS) classify it as harmful if swallowed (H302) and can cause skin and serious eye irritation (H315, H319). It may also cause respiratory irritation (H335) and drowsiness or dizziness (H336). Therefore, when working with this compound, it is imperative to:

  • Avoid inhalation of dust or vapors and prevent contact with skin and eyes.
  • Wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles with side shields, and a lab coat. In cases of potential dust generation or insufficient ventilation, a respirator may be necessary.
  • Ensure adequate ventilation in the workspace, preferably using a fume hood.
  • Store the chemical in a cool, dry, well-ventilated area, away from incompatible materials. Keep containers tightly sealed.
  • Handle with care, especially when transferring or weighing, to minimize dust formation.

For those looking to buy this chemical, it's important to source from reputable suppliers who provide comprehensive SDS and adhere to safety regulations. Understanding these properties and precautions ensures efficient and safe utilization of 4-Bromo-5-fluoro-2-nitrotoluene in your laboratory or manufacturing processes. Always consult the most current SDS provided by your manufacturer for the most accurate and up-to-date safety information.