In industrial chemical manufacturing, understanding the specific properties and optimal handling procedures for key intermediates is crucial for efficiency and safety. 4-Bromophenylacetonitrile (CAS 16532-79-9) is one such intermediate, valued for its role in the synthesis of pharmaceuticals and other fine chemicals. This article provides an overview of its key characteristics, industrial applications, and essential handling guidelines for manufacturers and plant operators.

Physicochemical Properties of 4-Bromophenylacetonitrile

4-Bromophenylacetonitrile (CAS 16532-79-9) is scientifically known as 2-(4-bromophenyl)acetonitrile. Its appearance is typically described as a colorless to pale brown crystalline mass. With a molecular formula of C8H6BrN and a molecular weight of approximately 196.04 g/mol, it possesses a distinct chemical structure that facilitates its use in various synthetic routes. Key physical properties include a density of around 1.487 g/cm³ and a relatively high boiling point of 286.2 °C at atmospheric pressure, indicating its stability under moderate heating. Its solubility is generally limited in water but good in common organic solvents like chloroform and ethyl acetate, which is advantageous for reaction processing and purification.

Industrial Applications and Benefits

The primary industrial application of 4-Bromophenylacetonitrile lies in its function as an intermediate for the production of Active Pharmaceutical Ingredients (APIs). Its brominated phenyl ring and nitrile group allow for versatile chemical transformations, enabling chemists to construct complex molecular frameworks required for new drug development. Manufacturers rely on this compound for its predictable reactivity and the ability to achieve high yields when used correctly. As a supplier, ensuring a consistent supply of this intermediate with high purity (≥99%) is vital for the continuous operation of pharmaceutical production lines. Sourcing from reliable manufacturers, particularly those based in China, can offer significant cost benefits without compromising on quality.

Safe Handling and Storage Practices

While 4-Bromophenylacetonitrile is a valuable industrial chemical, proper handling and storage are essential to ensure workplace safety and maintain product integrity. As a crystalline solid, it should be handled in well-ventilated areas to prevent inhalation of dust. Appropriate personal protective equipment (PPE), including gloves, safety glasses, and lab coats, should always be worn. Storage should be in tightly sealed containers, away from incompatible materials such as strong oxidizing agents, and protected from moisture and direct sunlight. Adhering to Material Safety Data Sheet (MSDS) recommendations is paramount. Manufacturers looking to buy this chemical should ensure their receiving and storage facilities are equipped to handle such compounds safely and efficiently.

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