For chemists, researchers, and procurement specialists in the chemical industry, a thorough understanding of a compound's properties is fundamental to its effective utilization. 5-Aminoindan-1-one (CAS: 3470-54-0) is a prime example of such a crucial chemical intermediate. Its unique structural features and reactivity make it a valuable component in various synthesis pathways, particularly within the pharmaceutical sector.

Chemical Identity and Structure

5-Aminoindan-1-one is an organic compound that belongs to the class of amino-indanones. Its chemical structure is characterized by a fused bicyclic system consisting of a benzene ring and a cyclopentanone ring, with an amino group attached to the benzene ring at the 5th position. This arrangement provides distinct chemical handles for further functionalization.

  • Chemical Name: 5-Aminoindan-1-one
  • Synonyms: 5-Amino-1-indanone, 5-Amino-2,3-dihydro-1H-inden-1-one, 5-Amino-1-oxoindane
  • CAS Registry Number: 3470-54-0
  • Molecular Formula: C9H9NO
  • Molecular Weight: Approximately 147.17 g/mol

Physical Properties

Understanding the physical characteristics of 5-Aminoindan-1-one is essential for handling, storage, and process design:

  • Appearance: Typically described as a solid. Specific reports mention it as a white or off-white crystalline solid.
  • Melting Point: Literature values indicate a melting point in the range of 184-186°C. This relatively high melting point suggests a stable solid form under standard conditions.
  • Solubility: Due to the presence of the polar amino group and carbonyl, it is generally soluble in polar organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), but sparingly soluble or insoluble in water.

Chemical Reactivity and Applications

The amino group on the aromatic ring can undergo typical reactions of primary amines, such as acylation, alkylation, and diazotization. The carbonyl group in the cyclopentanone ring can participate in nucleophilic addition reactions. These reactive sites make 5-Aminoindan-1-one a versatile building block:

  • Pharmaceutical Intermediates: Its primary application is as a key intermediate in the synthesis of pharmaceuticals, including compounds targeting neurological disorders.
  • Organic Synthesis: It serves as a valuable starting material for constructing more complex heterocyclic systems and functionalized organic molecules.

When sourcing 5-Aminoindan-1-one, it is crucial to consult the supplier's detailed specifications and Safety Data Sheet (SDS) for precise handling and storage instructions. For reliable supply and technical support, consider partnering with established chemical manufacturers and suppliers who can guarantee the purity and consistent quality of this important intermediate.