For chemists and procurement specialists involved in fine chemical synthesis, understanding the properties of key intermediates is fundamental to successful project execution. 3-Chloro-1,2-benzoxazole, identified by CAS Number 16263-52-8, is one such compound that warrants detailed examination. This article aims to shed light on its characteristics and provide guidance on sourcing this valuable chemical from reliable manufacturers.

Physically, 3-Chloro-1,2-benzoxazole is typically encountered as a white solid. Its melting point is a critical parameter for handling and storage, reported to be around 31°C. This relatively low melting point suggests it may be sensitive to elevated temperatures and requires appropriate storage conditions, often in a cool, dry place, sometimes under an inert atmosphere to maintain stability. Its molecular formula is C7H4ClNO, and its molecular weight is approximately 153.57 g/mol. These basic identifiers are crucial for accurate chemical inventory and reaction calculations.

Chemically, the presence of the chlorine atom on the benzoxazole ring imbues 3-Chloro-1,2-benzoxazole with significant reactivity. This makes it a potent intermediate for various organic transformations. The chlorine can be displaced by nucleophiles, or it can participate in metal-catalyzed cross-coupling reactions, enabling the introduction of diverse functional groups and extending molecular complexity. This versatility is what makes it attractive for applications in pharmaceutical intermediates, agrochemicals, and advanced materials research.

When it comes to sourcing 3-Chloro-1,2-benzoxazole, particularly from international markets, several factors are important. A primary concern for any buyer is the guaranteed purity of the compound. For critical applications, a purity of 97% min or higher is usually expected. Prospective buyers should look for suppliers who clearly state their purity levels and can provide robust analytical data, such as HPLC chromatograms or GC-MS reports, to substantiate these claims. Furthermore, understanding the scale of production offered by a manufacturer is key. Can they supply small research quantities as well as bulk industrial volumes?

China has become a significant global player in the chemical manufacturing sector, offering competitive pricing for a wide range of intermediates like 3-Chloro-1,2-benzoxazole. When approaching Chinese manufacturers or suppliers, clear communication regarding specifications, lead times, and shipping logistics is essential. Many reputable suppliers are adept at serving international clients and can provide comprehensive support, including free samples for evaluation. By diligently researching and selecting a trustworthy partner, businesses can ensure a stable and cost-effective supply of this important chemical intermediate.