For chemists and procurement specialists in the pharmaceutical and fine chemical industries, understanding the specific properties and synthesis routes of key intermediates is crucial for successful project execution. 2-Cyano-5-Fluorobenzyl Bromide (CAS: 421552-12-7) is one such compound, valued for its utility in various synthetic pathways. NINGBO INNO PHARMCHEM CO.,LTD. is a premier manufacturer and supplier of this essential chemical.

Key Properties of 2-Cyano-5-Fluorobenzyl Bromide

This compound typically presents as a white to almost white crystalline powder, with a molecular formula of C8H5BrFN and a molecular weight of 214.03 g/mol. Its melting point is around 69°C. The presence of the reactive benzylic bromide makes it an effective alkylating agent. The cyano group and the fluorine atom contribute to its distinct chemical reactivity and the potential for incorporating these features into target molecules, particularly in the pharmaceutical sector. Its solubility in common organic solvents like methanol is also a key factor in its ease of use during synthesis.

Synthesis Pathways for Reliable Production

The synthesis of 2-Cyano-5-Fluorobenzyl Bromide often involves the bromination of a precursor, such as 4-fluoro-2-methylbenzonitrile. A common method employs N-bromosuccinimide (NBS) as the brominating agent, typically in the presence of a radical initiator or under UV light, often in a solvent like carbon tetrachloride or dichloroethane. The reaction conditions, including temperature, reaction time, and catalyst, are optimized to maximize yield and purity while minimizing the formation of by-products. Purification steps, such as column chromatography, are usually necessary to obtain the high-purity product required for pharmaceutical applications. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. possess the expertise and infrastructure to carry out these syntheses efficiently and at scale, ensuring a consistent supply for the market.

Applications and Procurement Considerations

As a pharmaceutical intermediate, 2-Cyano-5-Fluorobenzyl Bromide is indispensable in the synthesis of various APIs, contributing to the development of novel drug candidates. Researchers looking to purchase this compound can expect to find it offered by specialized chemical manufacturers and suppliers. When sourcing, it is essential to look for suppliers who can provide:

  • Consistent product quality: Verified purity through CoA.
  • Reliable supply: Capacities to meet demand, especially for bulk orders.
  • Competitive pricing: Manufacturing efficiencies that translate to value for the buyer.
  • Accurate documentation: SDS and technical data to support safe handling and application.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to being a leading supplier of fine chemical intermediates. We ensure that our 2-Cyano-5-Fluorobenzyl Bromide is produced to the highest standards, making it an ideal choice for your synthesis needs. We invite you to inquire about pricing and availability to purchase this crucial intermediate for your projects.

Conclusion

Understanding the chemical properties, synthesis routes, and applications of 2-Cyano-5-Fluorobenzyl Bromide is key for professionals in the chemical and pharmaceutical industries. Its role as a versatile intermediate, particularly with its fluorine atom, makes it highly valuable. By partnering with trusted manufacturers like NINGBO INNO PHARMCHEM CO.,LTD., you can secure a dependable supply of this compound, supporting innovation and efficient production. Contact us to buy 2-Cyano-5-Fluorobenzyl Bromide and benefit from our expertise and quality products.