In the realm of pharmaceutical chemistry, understanding the intricate properties and synthesis pathways of key intermediates is crucial for successful drug development and manufacturing. This article delves into (2-Butyl-5-nitrobenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone (CAS No. 141645-23-0), a vital component in the production of Dronedarone hydrochloride. We will explore its physical and chemical characteristics, typical synthesis considerations, and why its consistent availability from reputable manufacturers is critical.

Chemical Identity and Physical Characteristics

(2-Butyl-5-nitrobenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone is an organic compound characterized by its molecular formula C30H40N2O5 and a molecular weight of approximately 508.65 g/mol. As a high-purity chemical intermediate, it is usually supplied as a white crystalline powder. This physical form simplifies handling and integration into various chemical processes. Its stability is generally good when stored under appropriate conditions, typically in a cool, dry, and well-closed container, away from moisture and strong light or heat. As a supplier, we emphasize proper storage to maintain product integrity.

Synthesis and Quality Control

The synthesis of this complex benzofuran derivative involves multi-step organic reactions, often requiring precise control of reaction conditions, reagents, and purification techniques to achieve the desired high purity (≥99%). While specific synthesis routes can vary, they typically focus on building the benzofuran core and introducing the necessary functional groups—the butyl chain, the nitro group, and the dibutylamino-propoxy side chain. For researchers and manufacturers looking to buy this compound, working with a manufacturer that employs stringent quality control measures is essential. This ensures that each batch meets the required specifications for downstream applications, such as API synthesis.

Applications in Pharmaceutical Synthesis

The primary application for (2-Butyl-5-nitrobenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone is its role as a key intermediate in the synthesis of Dronedarone hydrochloride. Dronedarone is a significant pharmaceutical agent used for the management of certain cardiac arrhythmias. Therefore, the demand for this intermediate is directly linked to the production needs of this life-saving drug. Pharmaceutical companies often seek reliable sources to purchase this compound for their API manufacturing processes. Understanding the price and availability from various suppliers, especially those based in China, is a common procurement strategy.

Procurement Considerations

When a pharmaceutical company decides to buy (2-Butyl-5-nitrobenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone, they typically conduct thorough supplier vetting. This includes reviewing the manufacturer's capabilities, quality assurance protocols, and their ability to supply consistently. Obtaining a detailed quotation that outlines pack sizes, purity levels, and current pricing is a standard step. Many R&D scientists and procurement managers find it beneficial to establish long-term relationships with trusted suppliers who can guarantee both product quality and supply chain reliability. If you are looking to purchase this critical intermediate, contacting an experienced supplier in China can offer competitive advantages.

In summary, (2-Butyl-5-nitrobenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone is a high-value pharmaceutical intermediate with specific physical and chemical properties vital for Dronedarone hydrochloride synthesis. Understanding these aspects and engaging with reliable manufacturers is key for successful procurement. For your sourcing needs, we are a dedicated supplier ready to provide you with this essential chemical.